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11-DEOXY PROSTAGLANDIN E2

11-DEOXY PROSTAGLANDIN E2 Structure
11-DEOXY PROSTAGLANDIN E2
  • CAS No.35536-53-9
  • Chemical Name:11-DEOXY PROSTAGLANDIN E2
  • CBNumber:CB5404539
  • Molecular Formula:C20H32O4
  • Formula Weight:336.47
  • MOL File:35536-53-9.mol
11-DEOXY PROSTAGLANDIN E2 Property
  • Boiling point 510.3±45.0 °C(Predicted)
  • Density 1.085±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMF: >100 mg/ml (from PGE2); DMSO: >100 mg/ml (from PGE2); Ethanol: >100 mg/ml (from PGE2); PBS pH 7.2: >5 mg/ml (from PGE2)
  • form A crystalline solid
  • pka 4.75±0.10(Predicted)
  • color White to off-white
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H302-H360
  • Precautionary statements P201-P202-P264-P270-P280-P301+P312-P330-P308+P313-P405-P501

11-DEOXY PROSTAGLANDIN E2 Chemical Properties,Usage,Production

  • Description 11-deoxy Prostaglandin E2 (11-deoxy PGE2) is a stable, synthetic analog of PGE2 . In contrast to PGE2 which has bronchodilation effects, 11-deoxy PGE2 is a powerful bronchoconstrictor and contracts human respiratory tract smooth muscle with potencies ranging from 5 to 30 times higher than PGF2α .
  • Uses 11-Deoxy Prostaglandin E2 is a selective agonist of EP4 with an EC50 of 0.66 nM. 11-Deoxy Prostaglandin E2 is an analog of prostaglandin E2. 11-Deoxy Prostaglandin E2 can be used in study bone healing, heart failure, and other receptor associated conditions[1][2].
  • Definition ChEBI: 11-Deoxy-PGE2 is a prostanoid.
  • References [1] Holt MC, et al. Improved homology modeling of the human & rat EP4 prostanoid receptors. BMC Mol Cell Biol. 2019 Aug 27;20(1):37. DOI:10.1186/s12860-019-0212-5
    [2] Ungrin MD, et al. Key structural features of prostaglandin E(2) and prostanoid analogs involved in binding and activation of the human EP(1) prostanoid receptor. Mol Pharmacol. 2001 Jun;59(6):1446-56. DOI:10.1124/mol.59.6.1446
11-DEOXY PROSTAGLANDIN E2 Preparation Products And Raw materials
Raw materials
Preparation Products
11-DEOXY PROSTAGLANDIN E2 Suppliers
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11-DEOXY PROSTAGLANDIN E2 Spectrum
35536-53-9, 11-DEOXY PROSTAGLANDIN E2Related Search:
  • 抑制剂
  • 35536-53-9
  • Prosta-5,13-dien-1-oic acid, 15-hydroxy-9-oxo-, (5Z,13E,15S)-
  • CTHZICXYLKQMKI-FOSBLDSVSA-N
  • 9-OXO-15S-HYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID
  • 11-DEOXY PROSTAGLANDIN E2

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