SIB 1893

Product NameSIB 1893
CAS6266-99-5
CBNumberCB5393055
MFC14H13N
MW195.26
MDL NumberMFCD02262120
MOL File6266-99-5.mol

Chemical Properties

storage temp.	2-8°C
solubility	DMSO: 18 mg/mL
form	solid
color	White to off-white

Safety

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3

SIB 1893 Chemical Properties,Usage,Production

Uses

SIB 1893 is a selective antagonist of mGluR-5. SIB 1893 acts as a positive allosteric modulator of human metabotropic mGlu4 (1). Anticonvulsant (2).

Definition

ChEBI: 2-methyl-6-(2-phenylethenyl)pyridine is a member of styrenes.

Biological Activity

A highly selective non-competitive antagonist for the metabotropic glutamate mGlu 5 receptor subtype; displays an IC 50 value of 0.3 μ M at hmGlu 5 , compared with > 100 μ M at hmGlu 1b , hmGlu 2 , hmGlu 6 , hmGlu 7 and hmGlu 8 . Centrally active upon systemic administration in vivo . Positive allosteric modulator at mGlu 4 receptors.

in vivo

(E)-SIB-1893 produces hypothermia in freely moving rats in a dose-dependent manner^[1].

SIB 1893 Supplier

Global(55)Suppliers

Region

CHINA 41 Germany 2 Japan 1 Switzerland 2 United Kingdom 2 United States 6 USA 1

Clear All Done

Supplier	Tel	Email	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	29624	60
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	32430	58
Career Henan Chemica Co	+86-0371-86658258 +86-13203830695	laboratory@coreychem.com	30202	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	19978	58
Wuhan Topule Biopharmaceutical Co., Ltd	+86-18327326525	masar@topule.com	8432	58
Aladdin Scientific		tp@aladdinsci.com	54731	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	53586	58
Shanghai Amole Biotechnology Co., Ltd.	13370042665 18916960931	3623107365@qq.com	17234	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	6206333 13167063860	anhua.mao@aladdin-e.com	49546	58
Aikon International Limited	025-58851090 19370895928	2850281427@qq.com	8014	58

SIB 1893 Spectrum

SIB 1893(6266-99-5)¹HNMR

6266-99-5(SIB 1893) Related Search

ETHYLENE
stilbazium iodide
SIB 1893
4-(1,3-Benzodioxol-5-yl)-2-[(E)-2-(3-chlorophenyl)ethenyl]-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile
4-(1,3-Benzodioxol-5-yl)-2-[(E)-2-(4-chlorophenyl)ethenyl]-5H-indeno[1,2-b]pyridin-5-one

4-(1,3-Benzodioxol-5-yl)-2-[(E)-2-(4-fluorophenyl)ethenyl]-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile
2-[(E)-2-(3-Chlorophenyl)ethenyl]-4-(4-heptylphenyl)-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile
4-(1,3-Benzodioxol-5-yl)-2-[(E)-2-(3-bromophenyl)ethenyl]-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile
4-(1,3-Benzodioxol-5-yl)-2-[(E)-2-(3-nitrophenyl)ethenyl]-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile
4-(2-Fluorophenyl)-2-[(E)-2-(3-methoxyphenyl)ethenyl]-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile

4-(1,3-Benzodioxol-5-yl)-2-(4-methoxystyryl)-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile
4-(1,3-Benzodioxol-5-yl)-2-[(E)-2-(2-chlorophenyl)ethenyl]-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile
4-(1,3-Benzodioxol-5-yl)-2-(3,4-dichlorostyryl)-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile
4-(1,3-Benzodioxol-5-yl)-2-[(E)-2-(2-fluorophenyl)ethenyl]-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile
4-(1,3-Benzodioxol-5-yl)-2-(4-hydroxystyryl)-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile

4-(1,3-Benzodioxol-5-yl)-2-(4-nitrostyryl)-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile
2-[(E)-2-(4-Fluorophenyl)ethenyl]-5-oxo-4-(3,4,5-trimethoxyphenyl)-5H-indeno[1,2-b]pyridine-3-carbonitrile

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