ChemicalBook > CAS DataBase List > 2,6-Difluorobenzamide

2,6-Difluorobenzamide

CAS No.18063-03-1
Chemical Name:2,6-Difluorobenzamide
CBNumber:CB5376515
Molecular Formula:C7H5F2NO
Formula Weight:157.12
MOL File:18063-03-1.mol

2,6-Difluorobenzamide Property

Melting point 145-148 °C (lit.)
Boiling point 51-52C/15Tor
Density 1,199g/cm
refractive index 1,508
storage temp. Sealed in dry,Room Temperature
solubility ethanol: soluble5%, clear to turbid, colorless to light yellow
form Solid
pka 14.54±0.50(Predicted)
color Off-White
BRN 2047480
InChIKey AVRQBXVUUXHRMY-UHFFFAOYSA-N
LogP 0.011-0.25 at 25℃
CAS DataBase Reference 18063-03-1(CAS DataBase Reference)
FDA UNII SJ2RN214MK
NIST Chemistry Reference Benzamide, 2,6-difluoro-(18063-03-1)
EPA Substance Registry System Benzamide, 2,6-difluoro- (18063-03-1)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :Xi,Xn
Risk Statements :36/37/38-20
Safety Statements :26-37/39-36/37
WGK Germany :1
RTECS :CV4355050
HazardClass :IRRITANT
HS Code :29242990
Toxicity :rat,LC50,inhalation,> 2100mg/m3/4H (2100mg/m3),National Technical Information Service. Vol. OTS0543293,

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302
Precautionary statements P264-P270-P301+P312-P501

2,6-Difluorobenzamide Price More Price(6)

Brand: Sigma-Aldrich(India)
Product number: 282278
Product name : 2,6-Difluorobenzamide
Purity: 97%
Packaging: 10G
Price: ₹3074.3
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 282278
Product name : 2,6-Difluorobenzamide
Purity: 97%
Packaging: 50G
Price: ₹5802.2
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: D1907
Product name : 2,6-Difluorobenzamide
Purity: min. 98.0 %
Packaging: 25G
Price: ₹3200
Updated: 2022/05/26
Buy: Buy

Brand: ALFA India
Product number: ALF-A11685-14
Product name : 2,6-Difluorobenzamide, 98+%
Purity:
Packaging: 25g
Price: ₹2988
Updated: 2022/05/26
Buy: Buy

Brand: ottokemi
Product number: D 1806
Product name : 2,6-Difluorobenzamide+
Purity: 97%
Packaging: 10gm
Price: ₹2808
Updated: 2022/05/26
Buy: Buy

2,6-Difluorobenzamide Chemical Properties,Usage,Production

Description 2,6-Difluorobenzamide is a major metabolite of pesticide diflubenzuron and has been quantitated by HPLC/diode-array method.
Description 2,6-Difluorobenzamide is a white powdery crystal, insoluble in water. It can be obtained by hydrolysis of 2,6-difluorobenzonitrile. 2,6-Difluorobenzamide is an important intermediate in the synthesis process of benzoylurea insecticides, which is used to synthesize the next intermediate 2,6-difluorobenzoyl isocyanate, and finally obtain flubolurea, pyruron, fluridin, lice mite urea and other pesticide varieties. It can also be directly used to synthesize pyruron and flubolea. 2,6-Difluorobenzamide can inhibit the bacterial cell division protein FtsZ[1].
Chemical Properties white to yellowish powder
Uses 2,6-Difluorobenzamide (CAS# 18063-03-1) is a useful building block used in the synthesis of (E)-3-methyleneisoindolin-1-ones via oxidative annulation acrylates. It is also used in the synthesis of pesticide intermediates, which can be used to produce various insecticides such as fluazuron, chlorpyrifos, and pyrethroids.
Preparation 2,6-Difluorobenzamide is obtained by hydrolysis of 2,6-difluorobenzonitrile.
Toxics Screening Level The Initial Threshold Screening Level (ITSL) for 2,6-Difluorobenzamide is 11 μg/m3 based on an annual averaging time.
References [1] Straniero V, et al. 2,6-Difluorobenzamide inhibitors of the bacterial cell division protein FtsZ: design, synthesis and Structure Activity Relationship study. ChemMedChem, 2017; 12: 1303-1318.