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Salicylhydroxamic acid

CAS No.89-73-6
Chemical Name:Salicylhydroxamic acid
CBNumber:CB5357798
Molecular Formula:C7H7NO3
Formula Weight:153.14
MOL File:89-73-6.mol

Salicylhydroxamic acid Property

Melting point 177 °C (dec.) (lit.)
Boiling point 276.03°C (rough estimate)
Density 1.3585 (rough estimate)
refractive index 1.5500 (estimate)
storage temp. Sealed in dry,Room Temperature
form Fine Crystalline Powder
pka pK (25°) 4.19
color Beige-pink
Water Solubility It is soluble in water.
Merck 14,8331
BRN 1210520
Stability Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.
CAS DataBase Reference 89-73-6(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 8Q07182D0T
EPA Substance Registry System N,2-Dihydroxybenzamide (89-73-6)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :Xn
Risk Statements :20/21/22-36/37/38-40
Safety Statements :22-26-36-24/25
WGK Germany :3
RTECS :VO6870000
HS Code :29242990

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H312+H332-H315-H319-H335-H351
Precautionary statements P202-P280-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313

Salicylhydroxamic acid Price More Price(4)

Brand: Sigma-Aldrich(India)
Product number: S607
Product name : Salicylhydroxamic acid
Purity: 99%
Packaging: 5G
Price: ₹1634.58
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: S607
Product name : Salicylhydroxamic acid
Purity: 99%
Packaging: 25G
Price: ₹5607.35
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: S0008
Product name : Salicylhydroxamic Acid
Purity:
Packaging: 5G
Price: ₹1800
Updated: 2022/05/26
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Brand: TCI Chemicals (India)
Product number: S0008
Product name : Salicylhydroxamic Acid
Purity:
Packaging: 25G
Price: ₹4600
Updated: 2022/05/26
Buy: Buy

Salicylhydroxamic acid Chemical Properties,Usage,Production

Chemical Properties It is a white needle crystal or off-white powder with a slow-heating melting point of 168°C. It is soluble in alcohol and ether and can be sublimated. When exposed to air, it progressively turns red. It is synthesized by combining methyl salicylate and hydroxylamine hydrochloride with sodium hydroxide, followed by acidification.
Uses Salicylhydroxamic acid is a collector with efficient chelating effect on rare metal oxide minerals. It is used in rare metal beneficiation and has the advantages of good selectivity and strong collecting power. Salicylhydroxamic acid is mainly used as a complexing agent or extractant for rare earth ore, copper oxide ore, lead-zinc oxide ore, gold ore, kaolin, etc., as well as organic synthesis intermediates.
Application Salicylhydroxamic acid has various applications, such as:
Synthesizing phenylboronic acid-based bioconjugates for chromatographic use.
Acting as a ligand to create complexes of Fe(III), Cu(II), Ni(II), and Zn(II).
Acting as a selective collector during the flotation technique for segregating oxide minerals.
Preparation The synthesis of salicylhydroxamic acid involved a two-step process. In the first step, methyl salicylate was prepared by esterifying salicylic acid with methanol using 28g (0.2 mol) of salicylic acid, 81 ml of methanol, and 8 ml of concentrated sulfuric acid. In the second step, hydroxylamine was coupled with the methyl salicylate. 13.9 g (0.2mol) of hydroxylamine was mixed with 200 ml of 10% sodium hydroxide solution and cooled. To this, 152.3g (0.1mol) of methyl salicylate was added in small portions with vigorous shaking after each addition to ensure complete dissolution. The mixture was allowed to stand for 36 hours, then acidified with 2M sulphuric acid and cooled. The precipitate was filtered, recrystallized from hot water containing a drop of acetic acid, recooled, and filtered. The yield of white precipitate collected and weighed was 14g of salicylhydroxamic acid.
Preparation and Characterization of Salicylhydroxamic acid and its Complexes with Iron (III), Cobalt (II) and Manganese (II)
Definition ChEBI: Salicylhydroxamic acid is a hydroxamic acid that is N-hydroxybenzamide carrying a phenolic hydroxy group at position 2. It has a role as an antibacterial drug, a trypanocidal drug, an EC 3.5.1.5 (urease) inhibitor and an EC 1.11.2.2 (myeloperoxidase) inhibitor. It is a member of phenols and a hydroxamic acid.
Purification Methods Crystallise the hydroxamic acid from acetic acid. [Beilstein 10 H 98.]