2-Methyinaphtho[1,2-d]thiazole

Chemical Properties

Synthesis

63512-54-9

108-24-7

2682-45-3

1. 1-Aminonaphthalene-2-thiol and 20 mg of sodium dodecyl sulfate were added to 20 mL of water and stirred until a homogeneous mixture was formed. 2. 7.5 mmol of ethanoic anhydride was slowly added to the mixture and stirring was continued for 5 minutes. 3. A precipitate was produced from the reaction mixture over a period of 5-10 minutes. 4. The precipitate was collected by filtration, washed twice with 1 mL of water, and subsequently dried under vacuum. 5. The un-precipitated reaction mixture was extracted twice with 25 mL of ethyl acetate. 6. Ethyl acetate was used to extract the unprecipitated reaction mixture twice.6. The organic layers were combined and dried over anhydrous sodium sulfate.7. The solvent was removed under reduced pressure using a rotary evaporator to give 2-methyl-β-naphthothiazole in 70% yield.

References