Description
5(S)-
HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-
LO on EPA.
1 It is metabolized to LTA
5, a key intermediate in the formation of the 5-
series leukotrienes. Alternatively, 5(S)-
HpEPE is reduced to 5(S)-
HEPE by peroxidases.
Uses
5(S)-HPEPE is an ester product.
Definition
ChEBI: 5S-HpEPE is a HPETE.
References
1. Kulkarni, P.S., Kaufman, P.L., and Srinivasan, B.D.
Eicosapentaenoic acid metabolism in cynomolgus and rhesus conjunctiva and eyelid J. Ocul. Pharmacol. 3(4),349-356(1987).
