Diazepam-d8

Description

Diazepam-d₈ is an analytical reference material that is intended for use as an internal standard for the quantification of diazepam by GC- or LC-MS. Diazepam is categorized as a benzodiazepine.^1,2 Diazepam-d₈ is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.

This product is a qualified Reference Material (RM) that has been manufactured and tested to meet ISO17025 and Guide 34 guidelines. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability of measurements. All traceable RMs may be distinguished by their CofAs and can be downloaded below using the batch number located on the product label. For a representative CofA please contact our technical support.

Uses

Diazepam-d8 is the deuterium labelled form of Diazepam (D416855), which is an anxiolytic; skeletal muscle relaxant, also used as anticonvulsant.

Definition

ChEBI: Diazepam is a 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5. It has a role as a xenobiotic, an environmental contaminant, an anxiolytic drug, an anticonvulsant and a sedative. It is a 1,4-benzodiazepinone and an organochlorine compound.

References

1. Rickels, K., Csanalosi, I., Greisman, P., et al. Ketazolam and diazepam in anxiety: A controlled study J. Clin. Pharmacol. 20(10),581-589(1980).
2. Birnir, B., Eghbali, M., Everitt, A.B., et al. Bicuculline, pentobarbital and diazepam modulate spontaneous GABA_A channels in rat hippocampal neurons Br. J. Pharmacol. 131(4),695-704(2000).