ChemicalBook > CAS DataBase List > Phytosphingosine

Phytosphingosine

CAS No.554-62-1
Chemical Name:Phytosphingosine
CBNumber:CB5289606
Molecular Formula:C18H39NO3
Formula Weight:317.51
MOL File:554-62-1.mol

Phytosphingosine Property

Melting point 102 °C
Boiling point 483.7±40.0 °C(Predicted)
Density 0.983
vapor pressure 0.2Pa at 20℃
refractive index 9 ° (C=1, Pyridine)
storage temp. −20°C
solubility Soluble in Ethanol (up to 2 mg/ml).
pka 11.91±0.45(Predicted)
form White to off-white solid.
color White
Water Solubility 2.6mg/L at 20℃
Stability Stable for 1 year from date of purchase as supplied. Solutions in ethanol may be stored at -20°C for up to 1 month.
InChI InChI=1S/C18H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20/h16-18,20-22H,2-15,19H2,1H3/t16-,17+,18-/m0/s1
InChIKey AERBNCYCJBRYDG-KSZLIROESA-N
SMILES C(O)[C@H](N)[C@H](O)[C@H](O)CCCCCCCCCCCCCC
LogP 6.2 at 22℃
EWG's Food Scores 1
FDA UNII GIN46U9Q2Q
UNSPSC Code 12352211
NACRES NA.25

Safety

WGK Germany :1
HS Code :29221990

NFPA 704:

	0
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P305+P351+P338

Phytosphingosine Price More Price(3)

Brand: Sigma-Aldrich(India)
Product number: P2795
Product name : Phytosphingosine hydrochloride
Purity:
Packaging: 5MG
Price: ₹27149.1
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: P1765
Product name : Phytosphingosine
Purity:
Packaging: 1G
Price: ₹6600
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: P1765
Product name : Phytosphingosine
Purity:
Packaging: 5G
Price: ₹17400
Updated: 2022/05/26
Buy: Buy

Phytosphingosine Chemical Properties,Usage,Production

Description Phytosphingosine is a sphingolipid with a hydroxyl group at the C4 position that is found mainly in fungi and plants but also in animals, including humans. It is metabolized to odd-numbered fatty acids with 2-hydroxy palmitic acid as an intermediate. Phytosphingosine dose-dependently induces cell death of CHO cells and inhibits carbachol-induced activation of phospholipase D (PLD) in CHO cells transfected with C. elegans muscarinic acetylcholine receptors. It is essential in the heat stress response in S. cerevisiae. [Matreya, LLC. Catalog No. 1330]
Chemical Properties Off-White Solid
Uses Phytosphingosine is a natural anti-microbial compound and it is involved in several cellular processes such as cell differentiation and anti-inflammation.
Uses phytosphingosine is a sphingolipid that can improve the overall condition of skin and hair. Some sources site anti-microbial and anti-inflammatory properties. Research indicates similar activity to retinoic acid, in which case it may be particularly beneficial for aging and photo-aging skin.
Definition ChEBI: Phytosphingosine is a sphingoid, an amino alcohol and a triol. It has a role as a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is functionally related to a N-acyl-beta-D-galactosylphytosphingosine and a sphinganine. It is a conjugate base of a phytosphingosine(1+).
Origin In 1884, chemist J.L.W coined the word phytosphingosine, which was taken from the term “sphingoid”, a major component in all biological membranes. There are four types of sphingoid bases and phytosphingosine is one of them. Phytosphingosine is a widely distributed natural sphingoid base and found in fungi, plants, and animals.
Flammability and Explosibility Not classified
Veterinary Drugs and Treatments Phytosphingosine is a unique topical antiseborrheic compound. It is in a class called ceramides which are waxy materials meant to meant to mimic the normal lipid composition of the stratum corneum. It may also have some antiinflammatory and antimicrobial properties.
References 1) Fischer et al. (2012), Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria; Antimicrob. Agents Chemother., 56 1157 2) Fischer et al. (2013), Sphingoid bases are taken up by Escherichia coli and Staphylococcus aureus and induce ultrastructural damage; Skin Pharmacol. Physiol., 26 36