ChemicalBook > CAS DataBase List > Isoprenaline hydrochloride

Isoprenaline hydrochloride

CAS No.51-30-9
Chemical Name:Isoprenaline hydrochloride
CBNumber:CB5276844
Molecular Formula:C11H18ClNO3
Formula Weight:247.72
MOL File:51-30-9.mol

Isoprenaline hydrochloride Property

Melting point 165-175 °C (dec.)(lit.)
Boiling point 192°C (rough estimate)
Density 1.2296 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. 2-8°C
solubility Freely soluble in water, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
form White solid
color White to Off-White
Water Solubility Soluble
BRN 3917363
Stability Stable, but may be air and light sensitive. Incompatible with strong oxidizing agents.
InChI InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H
InChIKey IROWCYIEJAOFOW-UHFFFAOYSA-N
SMILES C1(=CC=C(O)C(O)=C1)C(O)CNC(C)C.Cl
CAS DataBase Reference 51-30-9(CAS DataBase Reference)
FDA UNII DIA2A74855
EPA Substance Registry System Isoproterenol hydrochloride (51-30-9)
UNSPSC Code 41116107
NACRES NA.77

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-36
WGK Germany :2
RTECS :DO1925000
F :3-8-10
HS Code :29225090
Toxicity :LD50 oral in rabbit: 3070mg/kg

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H303-H315-H319-H335
Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Isoprenaline hydrochloride Price More Price(7)

Brand: Sigma-Aldrich(India)
Product number: I5627
Product name : Isoprenaline hydrochloride
Purity:
Packaging: 5G
Price: ₹5940
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: PHR2722
Product name : Isoproterenol Hydrochloride
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 250MG
Price: ₹17038.55
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: I5627
Product name : Isoprenaline hydrochloride
Purity:
Packaging: 25G
Price: ₹19440
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: I5627
Product name : Isoprenaline hydrochloride
Purity:
Packaging: 100G
Price: ₹61767.45
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 420355
Product name : Isoproterenol, Hydrochloride - CAS 51-30-9 - Calbiochem
Purity: Phenethylamine derivative.
Packaging: 100MG
Price: ₹5810
Updated: 2022/06/14
Buy: Buy

Isoprenaline hydrochloride Chemical Properties,Usage,Production

Description Isoprenaline hydrochloride is an FDA-approved injectable drug that is the hydrochloride form of isoprenaline and is used as a bronchodilator, adrenergic beta agonist, cardiotonic, and sympathomimetic. Selective beta-adrenergic agonist that increases cytoplasmic cAMP. promotes glycogenolysis and causes bronchodilation. Increases Cl- diffusion and potential difference in rabbit tracheal cells via nitric oxide production. In addition, it can be used as an inducer in an experimental rat model of induced myocardial infarction^[1].
Chemical Properties White or almost white, crystalline powder.
Uses Isoproterenol hydrochloride is used as a selective β-adrenergic agonist, increases cytosolic cAMP.
Uses Isoproterenol is a non-selective beta-adrenergic agonist. Isoproterenol is used in the treatment of bradycardia; bronchodilator.
Definition ChEBI: DL-Isoprenaline hydrochloride is a member of catechols.
brand name Isuprel (Hospira); Isuprel (Sanofi Aventis); Vapo- ISO (Fisons).
General Description Odorless white crystalline powder. Slightly bitter taste. Aqueous solutions turn brownish-pink upon prolonged exposure to air.
Air & Water Reactions May be sensitive to exposure to air and light. . Water soluble.
Reactivity Profile An acid organic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
Health Hazard SYMPTOMS: Symptoms of exposure to Isoprenaline hydrochloride may include tremors, nervous apprehension, palpitations of the heart, epigastric distress, cardiac arrhythmias, myocardial necrosis, cardiac arrest, tachycardia, headache, flushing of the skin, anginal pain, nausea, dizziness, weakness, and sweating.
Fire Hazard Flash point data for Isoprenaline hydrochloride are not available. Isoprenaline hydrochloride is probably combustible.
Biological Activity Standard selective β -adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β 2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo . Also available as part of the β -Adrenoceptor Agonist Tocriset™ and Mixed Adrenergic Tocriset™ .
Biochem/physiol Actions β-adrenoceptor agonist; increases cytosolic cAMP.
storage Store at RT
References [1] FANG WANG. Fucoxanthin averts isoprenaline hydrochloride-induced myocardial infarction in rats[J]. Pharmacognosy Magazine, 2020, 16 1: 214-220. DOI:10.4103/pm.pm\_357\_19.