SUN11602

SUN11602 Property

Hazard and Precautionary Statements (GHS)

SUN11602 Chemical Properties,Usage,Production

Uses SUN 11602 is a novel aniline compound, which mimics the neuroprotective mechanisms of basic fibroblast growth factor.
Biological Activity SUN11602 is an orally active basic fibroblast growth factor (bFGF, FGF2) mimetic th at protects against glutamate toxicity in primary r at cerebrocortical neuron (0.1-1 μM SUN11602; 150 μM glutamate) and murine hippocampal neuron cultures (0.3-3 μM SUN11602; 100 μM glutamate). When administered in vivo, SUN11602 exhibits therapeutic efficacy in a r at hippocampal-lesion model (1-10 mg/kg p.o. 24h post Aβ1-40 injection) and a murine MPTP-induced nigrostriatal degeneration model (2.5-5 mg/kg/day p.o.).
in vivo
In WT mice, SUN11602 increases the levels of newly synthesized Calb in cerebrocortical neurons and suppresses the glutamate-induced rise in intracellular Ca²⁺. This Ca²⁺-capturing ability of Calb allows the neurons to survive severe toxic conditions of glutamate^[1]. Oral administration of SUN11602 at the midpoint of Aβ1-40 and ibotenate injections attenuate short-term memory impairment in the Y-maze test, as well as spatial learning deficits in the water maze task. In addition, the SUN11602 treatment inhibits the increase of peripheral-type benzodiazepine-binding sites (PTBBS),which are a marker for gliosis^[3].

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SUN11602 Spectrum

704869-38-5, SUN11602Related Search:

抑制剂
生物试剂
药靶配体
化合物SUN 11602,10 MM DMSO 溶液
SUN 11602,碱性成纤维细胞生长因子(BFGF)类似物
化合物SUN 11602
704869-38-5
SUN11602, 10 mM in DMSO
Benzamide, 4-[[4-[[2-[(4-amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]-
inhibit,Fibroblast growth factor receptor,SUN11602,FGFR,Inhibitor,SUN-11602
SUN11602;SUN11602
CS-2504
4-[[4-[[2-[(4-Amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]benzamide
SUN11602