SU 5205

SU 5205 Property

Melting point 194-196 °C
Boiling point 435.3±45.0 °C(Predicted)
Density 1.306±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 5 mg/ml
form A crystalline solid
pka 12.69±0.20(Predicted)
color White to yellow

Safety

NFPA 704:

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H315-H319-H335
Precautionary statements P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

SU 5205 Chemical Properties,Usage,Production

Uses SU5205 is an inhibitor of VEGFR2 (FLK-1), with an IC50 of 9.6 μM[1].
Biological Activity SU5205 is an inhibitor of VEGF receptor 2 (VEGFR2/FLK-1) with IC50 of 9.6 μM.
in vitro

SU5205 inhibits ligand-induced endothelial mitogenesis for VEGF with an IC ₅₀ of 5.1 μM.
target
Target Value
VEGFR2
(Cell-free assay) 9.6 μM
IC 50 Flk-1: 9.6 μM (IC₅₀)
References [1] Huh S, et al. Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis. Biol Pharm Bull. 2010;33(7):1242-5. DOI:10.1248/bpb.33.1242
[2] Torsten K, et, al. Synthesis and radiopharmacological investigation of 3-[4'-[(18)F]fluorobenzylidene]indolin-2-one as possible tyrosine kinase inhibitor. Bioorg Med Chem. 2009 Nov 15; 17(22): 7732-42.

SU 5205 Preparation Products And Raw materials

Raw materials

Preparation Products

SU 5205 Suppliers

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SU 5205 Spectrum

3476-86-6, SU 5205Related Search:

抑制剂
药靶配体
化合物SU 5205,10 MM DMSO 溶液
3-(4-氟苯亚甲基)吲哚啉-2-酮
化合物SU 5205
SU5205游离态
3476-86-6
SU5205, 10 mM in DMSO
mitogenesis,Inhibitor,VEGFR2,Vascular endothelial growth factor receptor,FLK-1,SU-5205,endothelial,VEGFR,SU5205,inhibit
SU 5205; SU-5205; SU5205
2H-Indol-2-one, 3-[(4-fluorophenyl)methylene]-1,3-dihydro-
SU 5205

Target	Value
VEGFR2 (Cell-free assay)	9.6 μM