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3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide

3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Structure
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
  • CAS No.420831-40-9
  • Chemical Name:3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
  • CBNumber:CB52639218
  • Molecular Formula:C19H21BrN2O3S
  • Formula Weight:437.35
  • MOL File:420831-40-9.mol
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Property
  • Density 1.469±0.06 g/cm3(Predicted)
  • storage temp. Sealed in dry,2-8°C
  • solubility DMSO: ≥15mg/mL
  • form powder
  • pka 12.28±0.70(Predicted)
  • color white to tan
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
  • FDA UNII 308B6B695N
  • UNSPSC Code 12352200
  • NACRES NA.25
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36
  • Safety Statements  :26
  • WGK Germany  :3
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H319
  • Precautionary statements P305+P351+P338
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0152
  • Product name : AK-7
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹10879.13
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0152
  • Product name : AK-7
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹44046.93
  • Updated: 2022/06/14
  • Buy: Buy

3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Chemical Properties,Usage,Production

  • Description The sirtuin SIRT2 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates. It has roles in metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases, potentially including Alzheimer’s, Huntington’s, and Parkinson’s diseases. AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM). In culture, it diminishes neuronal cell death induced by mutant huntingtin fragment. In addition, AK-7 down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo.
  • Uses AK-7 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates it is also a selective SIRT2 inhibitor.
  • in vivo

    AK-7 (15 mg/kg/dose, i.p.) is brain-permeable in wild-type and HD mice[1]. AK-7 (10, 20 mg/kg, i.p.) improves the behavior and neuropathological phenotype and extends survival of R6/2 HD mice. AK-7 (20 mg/kg) ameliorates HD neuropathology in R6/2 mice. AK-7 also reduces the polyglutamine aggregation in R6/2 brain. In addition, AK-7 treated 140CAG mice show motor performance changes that parallel untreated wild-type mice, with the 20 mg/kg dose being most effective and significantly different from untreated 140CAG mice[2].

  • IC 50 SIRT2: 15.5 μM (IC50)
  • storage +4°C
  • References 1) Tylor et al. (2011), A brain-permeable small molecule that reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase; ACS Chem. Biol., 6 540 2) Chopra et al. (2012), The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington’s disease mouse models; Cell Rep., 2 1492
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Preparation Products And Raw materials
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3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Spectrum
420831-40-9, 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMideRelated Search:
  • 抑制剂
  • 药靶配体
  • 化合物AK-7,10 MM DMSO 溶液
  • 化合物 AK-7
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  • 420831-40-9
  • 3-(1-azepanylsulfonyl)-N-(3-bromophenyl)benzamide
  • AK-7, 10 mM in DMSO
  • SIRT2 Inhibitor II
  • SIRT2 INHIBITOR II;AK7;AK 7
  • CS-922
  • SIRT2 Inhibitor II, AK-7
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  • Benzamide, N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-
  • AK-7
  • 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
  • AK 7, >=98%
  • N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide SIRT2 Inhibitor,AK-7
  • SIRT2 Inhibitor,AK-7
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