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2-Bromo-3-fluoro-6-picoline

2-Bromo-3-fluoro-6-picoline Structure
2-Bromo-3-fluoro-6-picoline
  • CAS No.374633-36-0
  • Chemical Name:2-Bromo-3-fluoro-6-picoline
  • CBNumber:CB5252466
  • Molecular Formula:C6H5BrFN
  • Formula Weight:190.01
  • MOL File:374633-36-0.mol
2-Bromo-3-fluoro-6-picoline Property
  • Boiling point 185.6±35.0 °C(Predicted)
  • Density 1.592±0.06 g/cm3(Predicted)
  • storage temp. Inert atmosphere,Room Temperature
  • pka -0.91±0.10(Predicted)
  • form Solid
  • InChIKey KKVUMKHUMBXLMH-UHFFFAOYSA-N
  • CAS DataBase Reference 374633-36-0(CAS DataBase Reference)
  • UNSPSC Code 12352200
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • HS Code  :2933499090
  • NFPA 704:
    1
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H312-H315-H319-H332-H335-H302
  • Precautionary statements P261-P280-P304+P340-P305+P351+P338-P405-P501a
2-Bromo-3-fluoro-6-picoline Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: AGN00010
  • Product name : 2-Bromo-3-fluoro-6-methylpyridine
  • Purity: AldrichCPR
  • Packaging: 1G
  • Price: ₹27787.78
  • Updated: 2022/06/14
  • Buy: Buy

2-Bromo-3-fluoro-6-picoline Chemical Properties,Usage,Production

  • Synthesis 3-Amino-2-bromo-6-methylpyridine or 4-amino-2-bromo-6-methylpyridine (25.20 g, 134.73 mmol) was added to a mixture of water (78.1 mL) and conc. HCl (12.8 mL, 350.30 mmol), and then the mixture was cooled to 0 ℃. To it, sodium nitrite (18.6 g,269.46 mmol) was added portion-wise with stirring over 20 min while keeping the reaction temperature between –5 ℃and 0 ℃. After 10 min, 65 per cent hexafluorophosphoric acid solution (43.26 g, 296.41 mmol) was added dropwise with cooling, at which point many precipitates were formed. The precipitates were collected by filtration using a glass filter funnel, washed with cold water (2 × 50 mL) and diethyl ether (100 mL), and then dried in the air for 48 h. The solid was slowly heated to 100 ℃ (very exothermic), and a dark, oily material was formed after 10 min. The oil was basified with diluted NaOH solution to pH~10 and extracted with CH2Cl2 (2 × 150 mL). The combined organic layer was dried over anhydrous Na2SO4, filtered, and evaporated to dryness under reduced pressure. The residue was purified by MPLC on neutral alumina using hexane/EtOAc (10:1) as an eluent to afford 2-Bromo-3-fluoro-6-picoline.
2-Bromo-3-fluoro-6-picoline Preparation Products And Raw materials
Raw materials
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2-Bromo-3-fluoro-6-picoline Spectrum
374633-36-0, 2-Bromo-3-fluoro-6-picolineRelated Search:
  • Pyridine Series
  • Boronic Acid
  • Pyridines
  • Pyridine
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  • C6H11NBrF
  • 2-溴-3-氟-6-甲基吡啶(CAS号:374633-36-0)
  • 2-溴-3-氟-6-甲基吡啶2-BROMO-3-FLUORO-6-METHYLPYRIDINE
  • 2-溴-3-氟-6-甲基吡啶 1G
  • 2-溴-3-氟-6-甲基吡啶
  • 2-甲基-3-氟-6-溴吡啶
  • 2-溴-3-氟-6-甲基吡
  • 374633-36-0
  • 2-bromo-3-fluoro-6-methylpyridine
  • 2-BROMO-3-FLUORO-6-PICOLINE ISO 9001：2015 REACH
  • 2-Bromo-3-fluoro-6-methylpyridine,98%
  • Pyridine, 2-bromo-3-fluoro-6-methyl-
  • uoro-6-methyL
  • 2-Bromo-3-fL
  • 6-Bromo-5-fluoro-2-picoline
  • 2-BROMO-3-FLUORO-6-PICOLINE

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