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Chonglou Saponin VII

Chonglou Saponin VII Structure
Chonglou Saponin VII
  • CAS No.68124-04-9
  • Chemical Name:Chonglou Saponin VII
  • CBNumber:CB52519622
  • Molecular Formula:C51H82O21
  • Formula Weight:1031.2
  • MOL File:68124-04-9.mol
Chonglou Saponin VII Property
  • Melting point 243-245 °C (decomp)
  • Density 1.45±0.1 g/cm3(Predicted)
  • storage temp. -20°C, protect from light
  • solubility Soluble in methanol;
  • pka 12?+-.0.70(Predicted)
  • form powder
  • color White
  • Water Solubility sparingly soluble in water
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • HS Code  :29329990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Chonglou Saponin VII Chemical Properties,Usage,Production

  • Chemical Properties White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.
  • Uses Used for content determination/identification/pharmacological experiments, etc.
  • Biological Activity Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with inhibition of Akt/p38 MAPK and P-gp. It attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins (Bax and cytochrome c), and reduces the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1 and p-Akt. Paris saponin VII induces strong autophagy in K562/ADR cells, which can be used for leukemia research.
  • Pharmacology Chonglou saponin VII has the functions of anti-inflammatory, anti-tumor, anti-viral, lowering cholesterol, lowering blood pressure and so on.
  • in vitro

    Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. It significantly suppresses cell proliferation by cell cycle arrest in the G0 /G1 phase.

  • in vivo

    Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice.

  • target

    Akt

    p38

    Bcl-2

    Caspase-9

    Caspase-3

    PARP-1

Chonglou Saponin VII Preparation Products And Raw materials
Raw materials
Preparation Products
Chonglou Saponin VII Suppliers
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    BOC Sciences
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Chonglou Saponin VII Spectrum
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