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Alpidem

Alpidem Structure
Alpidem
  • CAS No.82626-01-5
  • Chemical Name:Alpidem
  • CBNumber:CB5241330
  • Molecular Formula:C21H23Cl2N3O
  • Formula Weight:404.33
  • MOL File:82626-01-5.mol
Alpidem Property
  • Melting point 136-138°C
  • Density 1.24±0.1 g/cm3(Predicted)
  • storage temp. Refrigerator
  • solubility DMSO: ≥10mg/mL
  • pka 4.74±0.50(Predicted)
  • form powder
  • color white to tan
  • FDA UNII I93SC245QZ
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P280-P305+P351+P338

Alpidem Chemical Properties,Usage,Production

  • Description Alpidem is an imidazopyridine antianxiety agent with anticonvulsant properties. It is claimed to be the first non-benzodiazepine anxiolytic to show selectivity for the omega-1 modulatory site of the GABA, receptors. Alpidem is reported to be superior to buspirone and similar to the benzodiazepines, but is significantly better tolerated with lower abuse potential.
  • Chemical Properties White to Off-White Solid
  • Originator Synthelabo (France)
  • Uses A peripheral benzodiazepine GABAA receptor ligand, a new anxiolytic
  • Definition ChEBI: Alpidem is a member of imidazoles.
  • brand name Ananxyl
  • Biochem/physiol Actions Alpidem is a potent antagonist of peripheral benzodiazepine receptor (PBR) that is located on the outer mitochondrial membrane and interacts with the mitochondrial permeability transition (MPT) pore. Alpidem is an anxiolytic drug from the imidazopyridine family. Alpidem acts selectively on the α3 receptor subtype and to a lesser extent at the α1 subtype (Kd of 0.33nM and 1.67nM respectively), of the benzodiazepine receptor.
  • Clinical claims and research Alpidem is an imidazopyridine partial agonist that also shows relative selectivity for the type I benzodiazepine receptor. Studies have shown an anxiolytic effect comparable with the classic benzodiazepines, but with an improved adverse effect profile (Pancheri et al. 1993). It has also been compared with buspirone in patients with generalized anxiety disorder and shown to be more rapidly effective and again to have a more favorable adverse effect profile (Legris et al. 1993). Longer-term studies with alpidem have shown that tolerance does not occur, and no significant problems of withdrawal on discontinuation were found (Chevalier et al. 1993). Alpidem was licensed in France for the treatment of anxiety but has now been suspended because of recent reports of alpidem-induced hepatic dysfunction. The reason for this is unclear, but it may be a reflection of the fact that alpidem also binds to peripheral benzodiazepine receptors, which are present in high density in the liver.
Alpidem Preparation Products And Raw materials
Raw materials
Preparation Products
Alpidem Suppliers
Global(61)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
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  • Email：marketing@targetmol.com
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  • Supplier： J & K SCIENTIFIC LTD.
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  • Supplier： LGM Pharma
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  • Email：inquiries@lgmpharma.com
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Alpidem Spectrum
82626-01-5, AlpidemRelated Search:
  • Intermediates & Fine Chemicals
  • Heterocycles
  • Aromatics
  • Aromatics Compounds
  • Pharmaceuticals
  • 抑制剂
  • 医药原料
  • 中枢神经系统用药
  • 药物
  • 精神病治疗药
  • 神经系统用药
  • C21H23Cl2N3O
  • 阿尔吡登,10 MM DMSO 溶液
  • 化合物 T26600
  • 阿吡坦价格
  • 6-氯-2-(4-氯苯基)-N,N-二丙基咪唑并[1,2-Α]吡啶-3-乙酰胺
  • 阿吡坦
  • 阿尔吡登
  • 82626-01-5
  • Alpidem, 10 mM in DMSO
  • inhibit,GABA Receptor,Gamma-aminobutyric acid Receptor,Inhibitor,Alpidem,γ-Aminobutyric acid Receptor
  • ALPIDEM USP/EP/BP
  • 6-Chloro-2-(4-chlorophenyl)-N，N-dipmpylimidazol[1，2-α]pyridine-3-acetamide
  • Ananxyl
  • SL-80．0342
  • inanxyl
  • IMidazo
  • 2-(6-Chloro-2-(4-chlorophenyl)iMidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetaMide
  • Unii-I93sc245qz
  • Imidazo(1,2-A)pyridine-3-acetamide, 6-chloro-2-(4-chlorophenyl)-N,N-dipropyl-
  • Alpidemum [latin]
  • Alpidemum
  • 6-Chlor-2-(4-chlorphenyl)-N,N-dipropylimidazol(1,2-A)pyridin-3-acetamid
  • 6-Chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-a]pyridine-3-acetamide
  • SL 80.0342-00
  • 6-Chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-α]pyridine-3-acetamide
  • 6-Chloro-2-(p-chlorophenyl)-N,N-dipropylimidazo(1,2-a)pyridine-3-aceta mide
  • ALPIDEM

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