Description
Enzymatically-derived Prostaglandin F
2α (PGF
2α) is an optically pure compound whereas PGF
2α derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture.
Ent-PGF
2α is the opposite enantiomer of PGF
2α. This compound can only be generated
via the isoprostane pathway of free radical-catalyzed lipid peroxidation and has been implicated as a marker of oxidative stress. Levels of
ent-PGF
2α are elevated in human urine from heavy cigarette smokers and patients with hypercholesterolemia.
