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BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT

BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT Structure
BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT
  • CAS No.71730-64-8
  • Chemical Name:BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT
  • CBNumber:CB5123834
  • Molecular Formula:C13H26N4O6
  • Formula Weight:334.37
  • MOL File:71730-64-8.mol
BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT Property
  • storage temp. -15°C
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT Chemical Properties,Usage,Production

  • Uses Threonyl-seryl-lysine, a bovine pineal antireproductive tripeptide, has antigonadotropic activity. Threonyl-seryl-lysine binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5[1][3].
  • Definition ChEBI: Thr-Ser-Lys is an oligopeptide.
  • in vivo

    Threonyl-seryl-lysine (175 ng, i.p.) reduces the 5-day compensatory ovarian hypertrophy in unilaterally ovariectomized (UO) mice[1].
    Threonyl-seryl-lysine (1 or 5 μg, i.p.) delays vaginal opening time in female Charles River CD rats[2].
    Threonyl-seryl-lysine (1 and 10 μg, s.c., for 15 days) increases the weight of ovaries and of adrenals in mice[4].

    Animal Model:Unilaterally ovariectomized (UO) mice
    Dosage:175 ng
    Administration:Intraperitoneal injection (i.p.)
    Result:Reduced serum follicle stimulating hormone (FSH) in UO mice.
  • References [1] Orts RJ, et al. Inhibitory properties of a bovine pineal tripeptide, threonylseryllysine, on serum follicle-stimulating hormone. Neuroendocrinology. 1980 Aug;31(2):92-5. DOI:10.1159/000123056
    [2] Benson B. Bovine pineal tripeptide threonylseryllysine retards puberty in female rats. J Pineal Res. 1989;6(4):351-7. DOI:10.1111/j.1600-079x.1989.tb00431.x
    [3] Root-Bernstein RS, et al. Bovine pineal antireproductive tripeptide binds to luteinizing hormone-releasing hormone: a model for peptide modulation by sequence specific peptide interactions? Brain Res Bull. 1986 Oct;17(4):519-28. DOI:10.1016/0361-9230(86)90219-4
    [4] Vaughan M K, et al. Influence of Thr-Ser-Lys (TSL), a recently isolated pineal peptide, on ovarian and uterine weights and estrous cycles in mice, hamsters and rats. Pineal function (Mathews CD, Seamark RF, eds.), 1981: 165-172.
BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT Preparation Products And Raw materials
Raw materials
Preparation Products
BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT Suppliers
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BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT Spectrum
71730-64-8, BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALTRelated Search:
  • 多肽
  • C13H26N4O6
  • 化合物 T26276
  • 71730-64-8
  • (2S)-6-amino-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]hexanoic acid
  • Bovine Pineal Antireproductive Tripeptide acetate salt H-Thr-Ser-Lys-OH acetate salt
  • BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT
  • BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE
  • BOVINE PINEAL ANTIREPRODUCTIVE PEPTIDE
  • THR-SER-LYS
  • Thr-Ser-Lys acetate salt
  • L-Lysine, N2-(N-L-threonyl-L-seryl)-
  • threonine-serine-lysine acetate
  • THR-SER-LYS (THR-SER-LYS ACETATE)
  • threonyl-seryl-lysine
  • thr-ser-lys acetate
  • H-Thr-Ser-Lys-OH
  • H-THR-SER-LYS-OH ACETATE SALT

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