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GERANYLGERANIOL

GERANYLGERANIOL Structure
GERANYLGERANIOL
  • CAS No.24034-73-9
  • Chemical Name:GERANYLGERANIOL
  • CBNumber:CB5120277
  • Molecular Formula:C20H34O
  • Formula Weight:290.48
  • MOL File:24034-73-9.mol
GERANYLGERANIOL Property
  • Boiling point 152-153 °C(Press: 0.07 Torr)
  • Density 0.8930 g/cm3(Temp: 18 °C)
  • storage temp. -20°C
  • solubility Chloroform (Sparingly), Dichloromethane (Slightly), Ethyl Acetate (Slightly)
  • form liquid
  • pka 14.42±0.10(Predicted)
  • color Colourless to Light Yellow
  • BRN 1913779
  • Stability Light Sensistive, Temperature Sensitive
  • InChIKey OJISWRZIEWCUBN-QIRCYJPOSA-N
  • FDA UNII AIA02AJA3A
  • UNSPSC Code 12352202
  • NACRES NA.77
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26-36
  • WGK Germany  :3
  • HS Code  :29052290
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338
GERANYLGERANIOL Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: G3278
  • Product name : Geranylgeraniol
  • Purity: ≥85% (GC)
  • Packaging: 100MG
  • Price: ₹7090.38
  • Updated: 2022/06/14
  • Buy: Buy

GERANYLGERANIOL Chemical Properties,Usage,Production

  • Chemical Properties Light Yellow Oil
  • Uses A intermediate in the lipidation of proteins, which plays a great importance for a variety of biological processes such as cell signalling
  • Uses Geranylgeraniol, a precursor to Geranylgeranylpyrophosphate (G367600), is an intermediate in the mevalonate pathway. Geranylgeraniol has been shown to prevent bone re-adsorption, inhibition of osteoclast formation, and kinase activation in vitro.
  • Definition ChEBI: Geranylgeraniol is a diterpenoid that is hexadeca-2,6,10,14-tetraene substituted by methyl groups at positions 3, 7, 11 and 15 and a hydroxy group at position 1. It has a role as a plant metabolite, a volatile oil component and an antileishmanial agent. It is a diterpenoid and a polyprenol.
  • Biochem/physiol Actions As the pyrophosphate, the metabolic precursor of all diterpenes. Screening in vitro shows this to be a potent and selective agent against Mycobacterium tuberculosis.
  • in vivo

    Geranylgeraniol (725 mg/kg/d; p.o.; 90 d) is not toxicologically significant with a dose below 725 mg/kg/d in rats[3].
    Geranylgeraniol (483 mg/kg/d; p.o.; 10 d) suppresses lipopolysaccharide-induced inflammation via inhibition of nuclear factor-κB activation in rats[4].

    Animal Model:Han Wistar rats (169-192 g for male; 116-152 g for female)[3]
    Dosage:0, 725, 1450, and 2900 mg/kg
    Administration:Oral gavage; once daily; 90 days
    Result:Showed the lowest observed adverse effect level (LOAEL) for local effects and the no observed adverse effect level (NOAEL) for systemic effects as 725 mg/kg/d.
    Reduced body weights by 12.9 and 21.6% in the intermediate- and high-dose group males, respectively, compared to controls.
    Animal Model:Wistar rats (male, 8-week-old, 130-150 g)[4]
    Dosage:0, 48.3, 483, 4830 mg/kg
    Administration:Oral gavage; once daily; 10 days; with or not LPS challenge (i.p.; 0.5 mg/kg)
    Result:Suppressed LPS-induced inflammatory cytokines and mRNA expression of LPS-induced inflammatory genes in liver with doses of 483 mg/kg and 4830 mg/kg.
    Suppressed protein levels of IRAK1, TRAF6, and TAK1, originating from transcriptional down-regulation with doses of 483 mg/kg and 4830 mg/kg.
GERANYLGERANIOL Preparation Products And Raw materials
Raw materials
Preparation Products
GERANYLGERANIOL Suppliers
Global(179)Suppliers
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  • Email：marketing@targetmol.com
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GERANYLGERANIOL Spectrum
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  • 24064-73-9
  • 香叶基香叶醇 98% 24034-73-9
  • 香叶基香叶醇,10 MM DMSO 溶液
  • 四烯甲萘醌杂质E
  • 替普瑞酮杂质26
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  • 香叶基香叶醇(GGOH)
  • (2E,6E,10E)-3,7,11,15-四甲基十六烷-2,6,10,14-四烯-1-醇
  • 香叶基香叶醇(E,E,E)-GERANYLGERANIOL
  • (2E,6E,10E)-3,7,11-15-四甲基-2,6,10,14-十六烷四烯-1-醇
  • 香叶基香叶醇
  • ALL TRANS-3,7,11-15-四甲基-2,6,10,14-十六烷四烯-1-醇
  • 24034-73-9
  • Geranylgeranio
  • Geranylgeraniol, 10 mM in DMSO
  • Menatetrenone ImpuritiesE
  • mitochondria,neuronal death,neuroinflammation,apoptosis,cholesterol pathway,NF-κB,inhibit,LPS-induced,Geranylgeraniol,microglial inflammation,Nuclear factor-kappaB,Nuclear factor-κB,mevalonate,Inhibitor
  • Tetraprenol
  • FT-0626663
  • FT0626663
  • CJ-24095
  • CJ24095
  • CJ 24095
  • TeprenoneImpurity26
  • (E,E,E)-Geranylgeranyl alcohol
  • (2e,6e,10e)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-ol
  • Geranylgeraniol (Natural) ~85%
  • GERANYLGERANIOL USP/EP/BP
  • Teprenone Impurity 26 (Geranylgeraniol)
  • Geranylgeraniol(GGOH)
  • Geranylgeraniol (Synthetic)
  • Geranylgeranyl Alcohol
  • 3,7,11,15-TETRAMETHYL-2,6,10,14-HEXADECATRAEN-1-OL
  • 3,7,11,15-TETRAMETHYL-2,6,10,14-HEXADECATETRAEN-1-OL
  • ALL TRANS GERANYL GERANIOL
  • ALL TRANS-3,7,11,15-TETRAMETHYL-2,6,10,14-HEXADECATETRAEN-1-OL
  • all-E-Geranylgeraniol
  • (2E,6E,10E)-3,7,11,15-Tetramethylhexadecane-2,6,10,14-tetrene-1-ol

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