Diproteverine
- Product NameDiproteverine
- CAS69373-95-1
- CBNumberCB51116554
- MFC26H35NO4
- MW425.565
- MDL NumberMFCD00864682
- MOL File69373-95-1.mol
Chemical Properties
Diproteverine Chemical Properties,Usage,Production
Uses
Diproteverine (BRL 40015) is an oral activity calcium channel blocker. Diproteverine embryonic toxicity. Diproteverine also shows antianginal properties[1][2].in vivo
Diproteverine (40, 80, 160, 320 mg/kg; p.o.; daily for 10 days) shows embryonic toxicity in rats[1].
| Animal Model: | Sprague-Dawley virgin female rats[1] |
| Dosage: | 40, 80, 160, 320 mg/kg |
| Administration: | P.o.; daily for 10 days |
| Result: | Induced embryonic deaths, significantly increased incidence of fetuses showing an unusual pattern of digital, tail, heart, and vertebral abnormalities. |
References
[1] Ridings JE, et al. Prenatal toxicity studies in rats and rabbits with the calcium channel blocker diproteverine. Reprod Toxicol. 1996 Jan-Feb;10(1):43-9. DOI:10.1016/0890-6238(95)02017-9[2] Lacroix P, et al. Diproteverine (BRL 40015): a new type of calcium antagonist with potential antianginal properties. Eur J Pharmacol. 1991 Jan 17;192(3):317-27. DOI:10.1016/0014-2999(91)90220-k
Diproteverine Suppliers
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