Uses
Wilforgine can be used as lymphocyte immunosuppression, with anti-tumor and anti-inflammatory effects, and can be used for content determination/identification/pharmacological experiments, etc.
Biological activity
Wilforgine is a bioactive sesquiterpene alkaloid in Tripterygium wilfordii Hook. F. Wilforgine can induce microstructural and ultrastructural changes in the muscles of Mythimna separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system.
Description
Wilforgine is a alkaloid,it from Tripterygiurn wilfordii Hook forms colourless plates from
MeOH-Me2CO. It is also dextrorotatory having [α]
25/sup>D + 25° (Me2CO)。
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Tripterygium wilfordii and Begonia truncatum.
Uses
Wilforgine is a bioactive sesquiterpene alkaloid in Tripterygium wilfordii Hook. F. Wilforgine can induce microstructural and ultrastructural changes in the muscles of Mythimna separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system[1][2].
Definition
ChEBI: A dihydroagarofuran sesquiterpenoid and pyridine alkaloid with formula C41H47NO19 originally isolated from the roots of Tripterygium wilfordii.
References
Beroza., J. Arner. Chern. Soc., 74, 1585 (1952)
Beroza., ibid, 75,44 (1953)
