Description Pharmacodynamics Features Side effects
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Dienogestrel

Description Pharmacodynamics Features Side effects
Dienogestrel Structure
Dienogestrel
  • CAS No.65928-58-7
  • Chemical Name:Dienogestrel
  • CBNumber:CB4947237
  • Molecular Formula:C20H25NO2
  • Formula Weight:311.43
  • MOL File:65928-58-7.mol
Dienogestrel Property
  • Melting point 210-2140C
  • alpha D25 -290° (c = 0.5 in pyridine)
  • Boiling point 451.46°C (rough estimate)
  • Density 1.0899 (rough estimate)
  • refractive index 1.5614 (estimate)
  • storage temp. 2-8°C
  • solubility Chloroform (Slightly), Pyridine (Slightly)
  • form powder
  • pka 13?+-.0.40(Predicted)
  • color white to beige
  • optical activity [α]/D -305 to -325°, c = 1 in dichloromethane
  • Merck 14,3106
  • InChI InChI=1/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/s3
  • InChIKey AZFLJNIPTRTECV-XAYGXGNENA-N
  • SMILES C[C@]12CCC3=C4CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@]2(O)CC#N |&1:1,14,16,20,r|
  • CAS DataBase Reference 65928-58-7(CAS DataBase Reference)
  • FDA UNII 46M3EV8HHE
  • NCI Drug Dictionary dienogest
  • ATC code G03DB08
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • RTECS  :RC8899500
  • HS Code  :2937.23.5050
  • Toxicity :LD50 oral in mouse: 4gm/kg
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H361
  • Precautionary statements P280
Dienogestrel Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1468
  • Product name : Dienogest
  • Purity: ≥98% (HPLC)
  • Packaging: 10MG
  • Price: ₹10684.28
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1468
  • Product name : Dienogest
  • Purity: ≥98% (HPLC)
  • Packaging: 50MG
  • Price: ₹43505.68
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D5230
  • Product name : Dienogest
  • Purity: 
  • Packaging: 50MG
  • Price: ₹6400
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D5230
  • Product name : Dienogest
  • Purity: 
  • Packaging: 250MG
  • Price: ₹9800
  • Updated: 2022/05/26
  • Buy: Buy

Dienogestrel Chemical Properties,Usage,Production

  • Description Dienoest is a selective progesterone drug that has been launched in recent years. It can stabilize endometrial tissue by specifically binding to ethylene nortestosterone and progesterone derivatives. Studies have found that tumor necrosis factor (TNF) and interleukin (IL-8) tend to increase in patients with endometriosis.
  • Pharmacodynamics Dienogest has progestogenic activity, possibly some antiprogestogenic activity, and has antiandrogenic activity.The medication does not interact with the estrogen receptor, the glucocorticoid receptor, or the mineralocorticoid receptor, and hence has no estrogenic, glucocorticoid, or antimineralocorticoid activity.Because of its relatively high selectivity as a progestogen, dienogest may have favorable safety and tolerability compared to various other progestins.
  • Features Dienogest is a mixed progestogen with dual properties of 19-nortestosterone derivatives and progesterone derivatives; therefore, it combines the pharmacological advantages of natural and synthetic progestins with high progestogenic activity .
  • Side effects Side effects associated with dienogestrel are the same as those expected of a progestogen.They include menstrual irregularities, headaches, nausea, breast tenderness, depression, acne, weight gain, flatulence, and others.Dienogest produces no androgenic side effects and has little effect on metabolic and lipid hemostatic parameters.
  • Physical properties Dienogestrel is a pale yellow solid.
  • Uses Dienogest is an orally active synthetic progesterone (or progestin). It is available for use as an oral contraceptive in combination with ethinylestradiol. It has antiandrogenic activity and as a result can improve androgenic symptoms.
  • Uses Derivative of 19-Nortestosterone. In combination with estrogen as oral contraceptive. Progestogen.
  • Definition ChEBI: A steroid hormone that is 17beta-hydroxy-3-oxoestra-4,9-diene substituted at position 17 by a cyanomethyl group. Used as an oral contraceptive.
  • brand name Endometrion (Schering A.G., Germany).
  • Biochem/physiol Actions Dienogest is used to treat endometriosis. It might also help to decrease the levels of plasma estradiol by stimulating cell death of granulosa cells in the ovary.
Dienogestrel Preparation Products And Raw materials
Raw materials
Preparation Products
Dienogestrel Suppliers
Global(399)Suppliers
  • Supplier：
    Henan Fengda Chemical Co., Ltd
  • Tel：+86-371-86557731<br/>+86-13613820652
  • Email：info@fdachem.com
  • Country：China
  • ProdList：20235
  • Advantage：58
Dienogestrel Spectrum
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