Description Uses Side effects Toxicity
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benzatropine

Description Uses Side effects Toxicity
benzatropine Structure
benzatropine
  • CAS No.86-13-5
  • Chemical Name:benzatropine
  • CBNumber:CB4875758
  • Molecular Formula:C21H25NO
  • Formula Weight:307.4293
  • MOL File:86-13-5.mol
benzatropine Property
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

benzatropine Chemical Properties,Usage,Production

  • Description Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970. 
    benzatropine.png
  • Uses Benzatropine is used to reduce extrapyramidal side effects of antipsychotic treatment. Benzatropine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor, and may alleviate rigidity and bradykinesia.Benzatropine is also sometimes used for the treatment of dystonia, a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face.
  • Side effects These are principally anticholinergic:Dry mouth;Blurred vision;Cognitive changes;Drowsiness;Constipation;Urinary retention;Tachycardia;Anorexia;Severe delirium and hallucinations (in overdose).
  • Toxicity The oral LD50 of benztropine is reported to be of 940 mg/kg in rats.In the presence of overdose with benztropine, it has been observed symptoms of circulatory collapse, cardiac arrest, respiratory depression, respiratory arrest, psychosis, shock, coma, seizure, ataxia, combativeness, anhidrosis, hyperthermia, fever, dysphagia, decreased bowel sounds and sluggish pupils.
  • Uses Antiparkinsonian.
  • Definition ChEBI: Tropane in which a hydrogen at position 3 is substituted by a diphenylmethoxy group (endo-isomer). An acetylcholine receptor antagonist, it is used (particularly as its methanesulphonate salt) in the treatment of Parkinson's disease, and to re uce parkinsonism and akathisia side effects of antipsychotic treatments.
  • brand name Cogentin (Merck).
  • Safety Profile Poison by subcutaneous andintravenous routes. When heated to decomposition itemits toxic fumes of NOx.
  • in vivo

    Benztropine (5 μM, 4 weeks) inhibits tumor-initiating potential in a 4T1 mouse model[1].

    Animal Model:Balb/c mice bearing 4T1 breast tumors[1]
    Dosage:1.5 mg/kg
    Administration:Injection; 3 weeks
    Result:Reduced the tumor size and weight significantly without body weight changing.
  • IC 50 D2 Receptor
benzatropine Preparation Products And Raw materials
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Preparation Products
benzatropine Suppliers
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  • Supplier： LGM Pharma
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  • Supplier： TargetMol Chemicals Inc.
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benzatropine Spectrum
86-13-5, benzatropineRelated Search:
  • 抑制剂
  • 化合物 BENZATROPINE
  • 化合物 T23781
  • 苯甲托品
  • 86-13-5
  • Benaztropine
  • NK 02
  • Cogentine
  • Akitan
  • 8-Azabicyclo[3.2.1]octane, 3-(diphenylmethoxy)-8-methyl-, (3-endo)-
  • GIJXKZJWITVLHI-PMOLBWCYSA-N
  • C06846
  • (1β,5β)-3α-(Diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane
  • (1β,3α,5β)-3-(Diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane
  • exo-Benztropine
  • (1S,5R)-3α-(Diphenylmethoxy)tropane
  • NISTC86135
  • benzatropine

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