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Disodium hydrogen phosphate dihydrate

CAS No.10028-24-7
Chemical Name:Disodium hydrogen phosphate dihydrate
CBNumber:CB4852564
Molecular Formula:2Na.HO4P.2H2O
Formula Weight:177.99
MOL File:10028-24-7.mol

Disodium hydrogen phosphate dihydrate Property

Melting point 92,5°C
bulk density 850-1000kg/m3
Density 1.064 g/mL at 20 °C
vapor density 4.9 (vs air)
storage temp. Store at +5°C to +30°C.
solubility H₂O: 0.5 M at 20 °C, clear, colorless
form powder
color White
PH 8.9-9.2 (25℃, 0.5M in H2O)
Odor Odorless
PH Range 9.1
Water Solubility Soluble in water
λmax λ: 260 nm Amax: 0.03
λ: 280 nm Amax: 0.03
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey KDQPSPMLNJTZAL-UHFFFAOYSA-L
CAS DataBase Reference 10028-24-7(CAS DataBase Reference)
FDA UNII 94255I6E2T
EPA Substance Registry System Disodium phosphate dihydrate (10028-24-7)
UNSPSC Code 12352302
NACRES NB.21

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-36-24/25-22
RIDADR :UN 3077 9 / PGIII
WGK Germany :3
RTECS :WC4500000
F :3
HS Code :28352200
Toxicity :LD50 orally in Rabbit: > 2000 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H315-H319-H335
Precautionary statements P261-P305+P351+P338

Disodium hydrogen phosphate dihydrate Price More Price(33)

Brand: Sigma-Aldrich(India)
Product number: 71645
Product name : Sodium phosphate dibasic dihydrate
Purity: BioXtra, ≥98.0% (T)
Packaging: 1KG
Price: ₹4124.33
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 71662
Product name : Sodium phosphate dibasic dihydrate
Purity: tested according to Ph. Eur.
Packaging: 1KG
Price: ₹6126.95
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 71645
Product name : Sodium phosphate dibasic dihydrate
Purity: BioXtra, ≥98.0% (T)
Packaging: 5KG
Price: ₹9558.48
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 71643
Product name : Sodium phosphate dibasic dihydrate
Purity: BioUltra, for molecular biology, ≥99.0% (T)
Packaging: 250G
Price: ₹4611.45
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 30435
Product name : Sodium phosphate dibasic dihydrate
Purity: puriss. p.a., reag. Ph. Eur., 98.5-101.0% (calc. to the dried substance)
Packaging: 500G
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Disodium hydrogen phosphate dihydrate Chemical Properties,Usage,Production

Chemical Properties The USP 32 states that dibasic sodium phosphate is dried or contains, 1, 2, 7, or 12 molecules of water of hydration. Anhydrous dibasic sodium phosphate occurs as a white powder. The dihydrate occurs as white or almost white, odorless crystals.
The heptahydrate occurs as colorless crystals or as a white granular or caked salt that effloresces in warm, dry air. The dodecahydrate occurs as strongly efflorescent, colorless or transparent crystals.
Chemical Properties solid
Uses Sodium phosphate dibasic dihydrate has been used for isolating DNA and RNA from bacterial samples of human gastrointestinal (GI) tract.
Uses Laxative.
Uses Sodium Phosphate Dibasic Dihydrate is a treatment of Ischemic stroke with aptamers targeting toll-like receptor 4 (TLR-4).
Production Methods Either bone phosphate (bone ash), obtained by heating bones to whiteness, or the mineral phosphorite is used as a source of tribasic calcium phosphate, which is the starting material in the industrial production of dibasic sodium phosphate.
Tribasic calcium phosphate is finely ground and digested with sulfuric acid. This mixture is then leached with hot water and neutralized with sodium carbonate, and dibasic sodium phosphate is crystallized from the filtrate.
Definition ChEBI: A hydrate that is the dihydrate form of disodium hydrogenphosphate
Pharmaceutical Applications Dibasic sodium phosphate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent. Therapeutically, dibasic sodium phosphate is used as a mild laxative and in the treatment of hypophosphatemia.
Dibasic sodium phosphate is also used in food products; for example as an emulsifier in processed cheese.
Biochem/physiol Actions Sodium phosphate dibasic dehydrate is an important component of running buffer of denaturing gel electrophoresis.
Safety Dibasic sodium phosphate is widely used as an excipient in parenteral, oral, and topical pharmaceutical formulations. Phosphate occurs extensively in the body and is involved in many physiological processes since it is the principal anion of intracellular fluid. Most foods contain adequate amounts of phosphate, making hypophosphatemia (phosphate deficiency) virtually unknown except for certain disease states or in patients receiving total parenteral nutrition. Treatment is usually by the oral administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract, virtually all of it being excreted in the urine, and the remainder is excreted in the feces.
Excessive administration of phosphate, particularly intravenously, rectally, or in patients with renal failure, can cause hyperphosphatemia that may lead to hypocalcemia or other severe electrolyte imbalances. Adverse effects occur less frequently following oral consumption, although phosphates act as mild saline laxatives when administered orally or rectally. Consequently, gastrointestinal disturbances including diarrhea, nausea, and vomiting may occur following the use of dibasic sodium phosphate as an excipient in oral formulations. However, the level of dibasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse effects.
LD50 (rat, oral): 17 g/kg
storage The anhydrous form of dibasic sodium phosphate is hygroscopic. When heated to 40℃, the dodecahydrate fuses; at 100℃ it loses its water of crystallization; and at a dull-red heat (about 240℃) it is converted into the pyrophosphate, Na4P2O7. Aqueous solutions of dibasic sodium phosphate are stable and may be sterilized by autoclaving.
The bulk material should be stored in an airtight container, in a cool, dry place.
Incompatibilities Dibasic sodium phosphate is incompatible with alkaloids, antipyrine, chloral hydrate, lead acetate, pyrogallol, resorcinol and calcium gluconate, and ciprofloxacin. Interaction between calcium and phosphate, leading to the formation of insoluble calcium-phosphate precipitates, is possible in parenteral admixtures.
Regulatory Status GRAS listed. Accepted in Europe for use as a food additive. Included in the FDA Inactive Ingredients Database (injections; infusions; nasal, ophthalmic, oral, otic, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.