ChemicalBook > CAS DataBase List > (Z,E)-5-(4-ETHYLBENZYLIDINE)-2-THIOXOTHIAZOLIDIN-4-ONE

(Z,E)-5-(4-ETHYLBENZYLIDINE)-2-THIOXOTHIAZOLIDIN-4-ONE

CAS No.403811-55-2
Chemical Name:(Z,E)-5-(4-ETHYLBENZYLIDINE)-2-THIOXOTHIAZOLIDIN-4-ONE
CBNumber:CB4820970
Molecular Formula:C12H11NOS2
Formula Weight:249.35
MOL File:403811-55-2.mol

(Z,E)-5-(4-ETHYLBENZYLIDINE)-2-THIOXOTHIAZOLIDIN-4-ONE Property

Density 1.33±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >10mg/mL
form Yellow solid
pka 7.72±0.30(Predicted)
color yellow
Water Solubility Soluble in DMSO. Soluble in water at concentrations less than 2mg/ml
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
UNSPSC Code 12352200
NACRES NA.77

Safety

Hazard Codes :Xi
Risk Statements :36-43
Safety Statements :26-36/37
WGK Germany :3
HazardClass :IRRITANT
HS Code :2934100090

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H317-H319
Precautionary statements P280-P302+P352-P305+P351+P338

(Z,E)-5-(4-ETHYLBENZYLIDINE)-2-THIOXOTHIAZOLIDIN-4-ONE Price More Price(5)

Brand: Sigma-Aldrich(India)
Product number: F3680
Product name : 10058-F4
Purity: ≥98% (HPLC), solid
Packaging: 5MG
Price: ₹7718.23
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: F3680
Product name : 10058-F4
Purity: ≥98% (HPLC), solid
Packaging: 25MG
Price: ₹30504.85
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 475956
Product name : c-Myc Inhibitor - CAS 403811-55-2 - Calbiochem
Purity: The c-Myc Inhibitor, also referenced under CAS 403811-55-2, controls the biological activity of c-Myc.
Packaging: 10MG
Price: ₹16670.01
Updated: 2022/06/14
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Brand: TCI Chemicals (India)
Product number: E0959
Product name : 5-(4-Ethylbenzylidene)rhodanine
Purity:
Packaging: 25MG
Price: ₹6900
Updated: 2022/05/26
Buy: Buy

Brand: ALFA India
Product number: ALF-J65650-MA
Product name : 10058-F4
Purity:
Packaging: 10mg
Price: ₹15205
Updated: 2022/05/26
Buy: Buy

(Z,E)-5-(4-ETHYLBENZYLIDINE)-2-THIOXOTHIAZOLIDIN-4-ONE Chemical Properties,Usage,Production

Description 10058-F4 (403811-55-2) effectively disables c-Myc by inhibiting the c-Myc-Max association and function.It prevents the growth of fibroblasts in a c-Myc-dependent manner. Downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells.10058-F4 induces cell cycle arrest, apoptosis and myeloid differentiation in human acute myeloid leukemia.Inhibits the MYCN/Max interaction leading to cell cycle arrest, apoptosis and neuronal differentiation in MYCN-amplified neuroblastoma cells.
Uses A c-Myc inhibitor that induces apoptosis
Definition ChEBI: 10058-F4 is a member of the class of thiazolidinones that is 2-sulfanylidene-1,3-thiazolidin-4-one which is substituted at position 5 by a (4-ethylphenyl)methylidene group. It is a cell permeable inhibitor of c-Myc-Max dimerization and exhibits antitumour effects in vivo. It downregulates c-Myc expression and upregulates CDK inhibitors, p21 and p27 resulting in the inhibition of proliferation, induction of apoptosis and cell cycle arrest in G0/G1 phase. It has a role as an apoptosis inducer and an antineoplastic agent. It is a thiazolidinone and an olefinic compound.
Biochem/physiol Actions 10058-F4 is a c-Myc inhibitor that induces cell-cycle arrest and apoptosis. 10058-F4 is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 inhibits tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 μM using c-Myc transfected Rat1a fibroblasts).
storage Store at +4°C
References 1) Yin?et al. (2003),?Low molecular weight inhibitors of Myc-Max interaction and function; Oncogene,?22?6151 2) Lin?et al. (2007),?Small-molecule c-Myc inhibitor, 10058-F4, inhibits proliferation, downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells; Anti-Cancer Drugs,?18161 3) Huang?et al. (2006),?A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia; Exp. Hematol.,?34?1480 4) Zirath?et al. (2013),?MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells; Proc. Natl. Acad. Sci. USA,?110?10258