Physical Form
ChemicalBook > CAS DataBase List > 3-chloro-4-(pyridin-2-ylmethoxy)aniline

3-chloro-4-(pyridin-2-ylmethoxy)aniline

Physical Form
3-chloro-4-(pyridin-2-ylmethoxy)aniline Structure
3-chloro-4-(pyridin-2-ylmethoxy)aniline
  • CAS No.524955-09-7
  • Chemical Name:3-chloro-4-(pyridin-2-ylmethoxy)aniline
  • CBNumber:CB4801557
  • Molecular Formula:C12H11ClN2O
  • Formula Weight:234.68
  • MOL File:524955-09-7.mol
3-chloro-4-(pyridin-2-ylmethoxy)aniline Property
  • Melting point 91.0 to 95.0 °C
  • Boiling point 402.5±35.0 °C(Predicted)
  • Density 1.292±0.06 g/cm3(Predicted)
  • storage temp. Keep in dark place,Inert atmosphere,Room temperature
  • form powder to crystal
  • pka 3.88±0.10(Predicted)
  • color White to Light yellow to Light orange
  • FDA UNII 67KD7Z8H49
Safety
  • HS Code  :2933399990
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P280-P302+P352-P305+P351+P338
3-chloro-4-(pyridin-2-ylmethoxy)aniline Price More Price(2)
  • Brand: TCI Chemicals (India)
  • Product number: C3150
  • Product name : 3-Chloro-4-(2-pyridylmethoxy)aniline
  • Purity: min. 98.0 %
  • Packaging: 1G
  • Price: ₹9000
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: C3150
  • Product name : 3-Chloro-4-(2-pyridylmethoxy)aniline
  • Purity: min. 98.0 %
  • Packaging: 5G
  • Price: ₹26500
  • Updated: 2022/05/26
  • Buy: Buy

3-chloro-4-(pyridin-2-ylmethoxy)aniline Chemical Properties,Usage,Production

  • Physical Form Solid
  • Uses 3-Chloro-4-(2-pyridylmethoxy)aniline was used for preparation of disubstituted (arylamino)quinolinecarbonitriles as orally active irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents.
  • Synthesis 3-chloro-4-(pyridin-2-ylmethoxy)aniline is synthesised using 2-((2-Chloro-4-nitrophenoxy)methyl)pyridine as a raw material by chemical reaction. The specific synthesis steps are as follows:
    The 2-((2-chloro-4-nitrophenoxy)methyl)pyridine (3.9 g, 15 mmol), zinc powder (5.8 g, 88 mmol) and ammonium chloride (2.4 g, 44 mmol) were added into a mixed solution of ethanol (60 mL) and H2O (10 mL). The mixture was stirred at 60° C. overnight. Then the reaction mixture was poured into 200 mL of H2O, extracted with ethyl acetate. The organic phase was separated, washed with saturated brine and dried. The solvent was removed in vacuo, and the compound shown in the title (3.4 g, 98percent) was obtained. 1H NMR (CDCl3): δ 8.57 (1H, d, J=4.8 Hz), 7.75-7.70 (1H, m), 7.65-7.63 (1H, m), 7.23-7.20 (1H, m), 6.81 (1H, d, J=9.2 Hz), 6.77 (1H, d, J=2.8 Hz), 5.18 (2H, s), 3.48 (2H, br).
    3-chloro-4-(pyridin-2-ylmethoxy)aniline synthesis
3-chloro-4-(pyridin-2-ylmethoxy)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
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3-chloro-4-(pyridin-2-ylmethoxy)aniline Spectrum
524955-09-7, 3-chloro-4-(pyridin-2-ylmethoxy)anilineRelated Search:
  • 524955-09-7
  • 抑制剂
  • 医用原料
  • 高端化学
  • 来那替尼
  • 化工中间体
  • 来那替尼中间体
  • 必定系列
  • 奈拉替尼中间体
  • 原料药及其中间体
  • 吡啶
  • 化合物 3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)ANILINE
  • 3-氯-4-(吡啶-2-甲氧基)苯基]甲胺(来那替尼杂质)
  • 来那替尼杂质41
  • [3-氯-4-(吡啶-2-甲氧基)苯基]甲胺(莱纳替尼侧链)
  • [3-氯-4-(吡啶-2-甲氧基)苯基]甲胺 1KG
  • 3-氯-4-(2-吡啶基甲氧基)苯胺
  • 3-氯-4-(吡啶-2基甲氧基)苯胺
  • 来那替尼中间体
  • 来那替尼-SM2
  • 3-氯-4-((吡啶-2-甲基)苯基)甲胺
  • 3-氯-4-(吡啶-2-甲氧基)苯胺
  • [3-氯-4-(吡啶-2-甲氧基)苯基]甲胺
  • 524955-09-7
  • 524955-09-73-Chloro-4-(pyridin-2-yloxy)aniline
  • 3-chloro-4-(2-pyridinylmethoxy) benzeneamine
  • 3-chloro-4-(pyridin-2-ylmethoxy)aniline
  • 3-Chloro-4-(pyridin-2-ylmethoxy)aniline (Neratinib Impurity)
  • 3-Chloro-4-[(pyridin-2-yl)Methyloxy]aniline
  • 3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-BENZENAMINE
  • 524955-09-7 AKOS B033273
  • Neratinib Impurity 41
  • AKOS B033273 ISO 9001：2015 REACH
  • oro-4-(2-pyridyL
  • methoxy)aniL
  • 4-((pyridin-2-yl)methoxy)-3-chlorobenzenamine
  • AKOS B033273(524955-09-7)
  • 3-Chloro-4-(pyridine-2-ylmethoxy)aniline
  • 3-Chloro-4-(2-pyridylmethoxy)aniline
  • 3-Chloro-4-(pyridin-2-ylmethoxy)
  • Neratinib Intermediate1
  • BenzenaMine, 3-chloro-4-(2-pyridinylMethoxy)-
  • 3-Chloro-4-[(pyridin-2-yl)Methoxy]benzenaMine [3-Chloro-4-(pyridin-2-ylMethoxy)phenyl]aMine
  • 3-chloro-4-(2-pyridinylMethoxy)- BenzenaMine
  • UKRORGSYN-BB BBV-019513
  • ART-CHEM-BB B033273
  • 3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-PHENYLAMINE
  • AKOS B033273

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