Description
Peptide agonist for galanin receptors, showing selectivity for GAL2 (Ki values are 85, 9 and 16 nM at rat GAL1, GAL2 and GAL3 receptors respectively).
Uses
Galanin (2-29) (rat) inhibits rat pancreatic protein and CCK-8-stimulated amylase secretion. Galanin (2-29) (rat) is an GAL2R agonist (Ki: 3.5 nM)[1][2].
References
[1] Rossowski WJ, et al. Galanin: structure-dependent effect on pancreatic amylase secretion and jejunal strip contraction. Eur J Pharmacol. 1993 Aug 24;240(2-3):259-67. DOI:
10.1016/0014-2999(93)90907-y[2] Wang S, et al. Molecular cloning and pharmacological characterization of a new galanin receptor subtype. Mol Pharmacol. 1997 Sep;52(3):337-43. DOI:
10.1124/mol.52.3.337
