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4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE

4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Property

storage temp. -20°C
solubility H₂O: ~2 μM Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media.
form solid
color white
Water Solubility H2O: ~2μM
DMSO: soluble
ethanol: soluble
Sensitive Light Sensitive
UNSPSC Code 12352211
NACRES NA.77

Safety

Hazard and Precautionary Statements (GHS)

4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Price More Price(1)

4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Chemical Properties,Usage,Production

Uses 4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.
Biochem/physiol Actions Negative control for phorbol ester activation of protein kinase C.

4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Spectrum

63597-44-4, 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATERelated Search:

metabolite
抑制剂
BioChemical
Cell Biology
Cell Signaling and Neuroscience
Kinase/Phosphatase Biology
Protein Kinase C (PKC)
Serine/Threonine Kinase Activators
化合物 4Α-TPA
4Α-佛波醇12-十四酸酯13-乙酸酯
4Α-12-O-十四碳酰基佛波醇13-乙酸酯
4ALPHA-12-O-十四碳酰基佛波醇13-乙酸酯
63597-44-4
4a-Phorbol 12-Myristate 13-Acetate
4α-Phorbol 12-myristate 13-acetate
alpha-TPA
Tetradecanoic acid,(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-ylester
4ALPHA-TPA
4ALPHA-PMA
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
4-ALPHA-12-TETRADECANOYL PHORBOL 13-ACETATE
4ALPHA-12-O-TETRADECANOYLPHORBOL 13-ACETATE
4-alpha-PMA, 4-alpha-TPA
4-α-Phorbol-12-Myristate-13-acetate / 4-α-12-Tetradecanoyl phorbol-13-acetate
4-alpha-Phorbol 12-Myristate 13-Acetate >99%
4α-TPA
(1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9-myristate 9a-acetate
4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%
4α-pma
4-A-PHORBOL 12-MYRISTATE-13-ACETATE NEGA TIVE CONTROL