ChemicalBook > CAS DataBase List > 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE

1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE

1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE Structure
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE
  • CAS No.67469-57-2
  • Chemical Name:1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE
  • CBNumber:CB4726281
  • Molecular Formula:C28H32N2O
  • Formula Weight:412.57
  • MOL File:67469-57-2.mol
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE Property
  • Melting point >200°C (dec.)
  • Boiling point 551℃
  • Density 1.085
  • Flash point 148℃
  • storage temp. Desiccate at -20°C
  • solubility Methanol (Slightly), Water (Slightly, Heated)
  • form Solid
  • color White to Off-White
  • FDA UNII 96Y892TJ2A
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

  • Chemical Properties White to off-white powder
  • Uses GBR 12783 is a very potent and selective inhibitor of dopamine uptake.
  • Definition ChEBI: 1-[2-(diphenylmethyl)oxyethyl]-4-(3-phenylprop-2-enyl)piperazine is a diarylmethane.
  • Biological Activity A very potent and selective inhibitor of dopamine uptake (IC 50 for inhibition of [ 3 H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM).
  • in vivo

    GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1].

    Animal Model:Male Sprague-Dawley rats (180-200 g)[1]
    Dosage:10 mg/kg
    Administration: Intraperitoneal injection; for 100 minutes
    Result:For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE Preparation Products And Raw materials
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1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE Spectrum
67469-57-2, 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDERelated Search:
  • Dopamine receptor
  • 抑制剂
  • 生化试剂
  • 合成
  • 活性候选物，Dopamine receptor
  • C28H32N2O2HCl
  • 化合物 GBR 12783
  • GBR 12783 二盐酸盐
  • 化合物 T11371
  • 1-(2-(苯甲酰氧基)乙基)-4-肉桂基哌嗪
  • 1-[2-(二苯基甲氧基)乙基]-4-(3-苯基-2-丙烯-1-基)哌嗪
  • 1-(2-二苯甲氧乙基)-4-(3-苯基-2-丙烯基)哌啶二盐酸盐
  • 67469-57-2
  • Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)-
  • 1-(2-(Benzhydryloxy)ethyl)-4-cinnamylpiperazine
  • CS-1338
  • 1-[2-(diphenylMethoxy)ethyl]-4-(3-phenylprop-2-en-1-yl)piperazine dihydrochloride
  • 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)piperazine
  • GBR-12783
  • 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine
  • GBR 12921
  • GBR127832HCl
  • GBR 12783 DIHYDROCHLORIDE
  • 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE
  • Piperazine,1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)-

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