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Amfepramone hydrochloride

CAS No.134-80-5
Chemical Name:Amfepramone hydrochloride
CBNumber:CB4676232
Molecular Formula:C13H20ClNO
Formula Weight:241.76
MOL File:134-80-5.mol

Amfepramone hydrochloride Property

Melting point 180-1810C
Flash point 9℃
storage temp. Controlled Substance, -20°C Freezer
solubility DMF: 1.25 mg/ml; DMSO: 3 mg/ml; Ethanol: 3 mg/ml; Methanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
form A crystalline solid
FDA UNII 19V2PL39NG
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :F,T
Risk Statements :11-23/24/25-39/23/24/25-20/21/22
Safety Statements :7-16-36/37-45-36
RIDADR :UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany :1
HS Code :2922310000

NFPA 704:

	0
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H225-H301+H311+H331-H370
Precautionary statements P210-P233-P280-P301+P310-P303+P361+P353-P304+P340+P311

Amfepramone hydrochloride Price More Price(1)

Brand: Sigma-Aldrich(India)
Product number: D-121
Product name : Diethylpropion hydrochloride solution
Purity: 1.0?mg/mL in methanol (with 1% 1 M HCl; as free base), certified reference material, Cerilliant?
Packaging: 1ML
Price: ₹10546.9
Updated: 2022/06/14
Buy: Buy

Amfepramone hydrochloride Chemical Properties,Usage,Production

Chemical Properties Off-White Solid
Originator Tenuate,Merrell National ,US,1959
Uses Controlled substance (stimulant). Anorexic.
Definition ChEBI: The hydrochloride salt of diethylpropion. A central stimulant and indirect-acting sympathomimetic, it is an appetite depressant and is used as an anoretic in the short term management of obesity.
Manufacturing Process 1,145 g of α-bromopropiophenone and 850 g of diethylamine are combined under stirring and heated on a water bath to boiling. The precipitate is filtered off under suction and washed with benzol. The filtrate is shaken up with aqueous hydrogen chloride, the aqueous solution made alkaline and etherified. The solution freed of the ether is fractionated. The boiling point (6 mm) is 140°C and the yield 800 g. The base is dissolved in acetic ester and precipitated with isopropanolic hydrogen chloride. After suction filtration and washing with ether the yield is found to be 750 g (80%)and the melting point 168°C.
Therapeutic Function Anorexic
General Description Because it has two large (relative to H or methyl) N-alkylsubstituents, diethylpropion hydrochloride, 1-phenyl-2-diethylaminopropan-1-one hydrochloride (Tenuate, Tepanil),has fewer sympathomimetic, cardiovascular, and CNSstimulatoryeffects than amphetamine. It is reportedly ananorexiant agent that can be used for the treatment of obesityin patients with hypertension and cardiovascular disease.According to the generalization long used for thisgroup of drugs, increasing N-alkyl size reduces central 1effects and increases β effects, even though the effects arelikely mediated principally by indirect NE release.