134-80-5

Name	Amfepramone hydrochloride
CAS	134-80-5
EINECS(EC#)	205-156-5
Molecular Formula	C13H20ClNO
MDL Number	MFCD00058013
Molecular Weight	241.76
MOL File	134-80-5.mol

Chemical Properties

Appearance	Off-White Solid
Melting point	180-1810C
Fp	9℃
storage temp.	Controlled Substance, -20°C Freezer
solubility	DMF: 1.25 mg/ml; DMSO: 3 mg/ml; Ethanol: 3 mg/ml; Methanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
form	A crystalline solid

Safety Data

Hazard Codes	F,T
Risk Statements	11-23/24/25-39/23/24/25-20/21/22 less more
Safety Statements	7-16-36/37-45-36 less more
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	1
HS Code	2922310000

Hazard Information

Chemical Properties

Off-White Solid

Uses

Controlled substance (stimulant). Anorexic.

Definition

ChEBI: The hydrochloride salt of diethylpropion. A central stimulant and indirect-acting sympathomimetic, it is an appetite depressant and is used as an anoretic in the short term management of obesity.

Originator

Tenuate,Merrell National ,US,1959

Manufacturing Process

1,145 g of α-bromopropiophenone and 850 g of diethylamine are combined under stirring and heated on a water bath to boiling. The precipitate is filtered off under suction and washed with benzol. The filtrate is shaken up with aqueous hydrogen chloride, the aqueous solution made alkaline and etherified. The solution freed of the ether is fractionated. The boiling point (6 mm) is 140°C and the yield 800 g. The base is dissolved in acetic ester and precipitated with isopropanolic hydrogen chloride. After suction filtration and washing with ether the yield is found to be 750 g (80%)and the melting point 168°C.

Therapeutic Function

Anorexic

General Description

Because it has two large (relative to H or methyl) N-alkylsubstituents, diethylpropion hydrochloride, 1-phenyl-2-diethylaminopropan-1-one hydrochloride (Tenuate, Tepanil),has fewer sympathomimetic, cardiovascular, and CNSstimulatoryeffects than amphetamine. It is reportedly ananorexiant agent that can be used for the treatment of obesityin patients with hypertension and cardiovascular disease.According to the generalization long used for thisgroup of drugs, increasing N-alkyl size reduces central 1effects and increases β effects, even though the effects arelikely mediated principally by indirect NE release.

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