Chemical Properties
CLEAR YELLOW TO BROWNISH LIQUID
Uses
3-Chloro-2-butanone was used in production of chiral alcohols from acetophenone derivatives, β-ketoesters and
N-
Boc-3-pyrrolidinone by recombinant
E. coli cells. It was used in the synthesis of carbene precursor, 3-aryl-4,5-dimethylthiazolium chloride.
Uses
3-Chloro-2-butanone was used to study various carbonylic compounds as substrates for 4-hydroxyacetophenone monooxygenase from
Pseudomonas fluorescens ACB.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 5274, 1955
DOI: 10.1021/ja01625a016
General Description
3-Chloro-2-butanone reacts with 1,4-dianion of acetophenone
N-ethoxycarbonylhydrazone to yield pyrazoline derivatives.
Synthesis
In a 250-mL three-necked flask equipped with a stirrer, constant pressure funnel and condenser tube, 43.27 g, 0.6 mol of butanone XVI and 36% HCl 30.42 g, 0.3 mol, added copper chloride 8.1 g, 0.06 mol, at 35 degrees Celsius, 30% H2O 249.23 g, 0.39 mol in 15 minutes slowly added dropwise, after completion, warmed to 78 degrees Celsius reflux reaction for 5 hours, the reaction solution was cooled to room temperature, the organic phase was separated, washed twice with saturated sodium carbonate solution, anhydrous sodium sulfate drying, fractional distillation to collect 137-140 degrees Celsius fraction, to obtain a brown liquid 3-chloro-2-butanone 8.0 grams, yield of 12.6%; _x000D _
