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GELSEMINE

GELSEMINE Structure
GELSEMINE
  • CAS No.509-15-9
  • Chemical Name:GELSEMINE
  • CBNumber:CB4391074
  • Molecular Formula:C20H22N2O2
  • Formula Weight:322.4
  • MOL File:509-15-9.mol
GELSEMINE Property
  • Melting point 181-183°C
  • alpha D20 +13° (c = 1.2 in chloroform)
  • Boiling point 461.02°C (rough estimate)
  • Density 1.1478 (rough estimate)
  • refractive index 1.5700 (estimate)
  • storage temp. 2-8°C
  • solubility Chloroform (Slightly), Methanol (Slightly)
  • form powder
  • pka 7.75 in 80% methylcellosolve
  • color White
  • LogP 3.080 (est)
  • EWG's Food Scores 1
  • FDA UNII 5Y13A78Z72
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319
  • Precautionary statements P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

GELSEMINE Chemical Properties,Usage,Production

  • Uses Medicine, as a CNS stimulant
  • Hazard A toxic plant alkaloid
  • in vivo

    Gelsemine is an effective agent for treatment of both neuropathic pain and sleep disturbance in partial sciatic nerve ligation (PSNL) mice. Gelsemine (4 mg/kg) exerts analgesic effects on PSNL-induced mechanical allodynia and thermal hyperalgesia. In PSNL mice, Gelsemine (2 and 4 mg/kg) increases the mechanical threshold for 4 h and prolonged the thermal latencies for 3 h. Furthermore, Gelsemine (4 mg/kg, administered at 6:30 AM) increases non-rapid eye movement (non-REM, NREM) sleep, decreases wakefulness, but does not affect rapid eye movement (REM) sleep during the first 3 h in PSNL mice[1].
    Immunohistochemical study shows that PSNL increases c-Fos expression in the neurons of the anterior cingulate cortex, and Gelsemine (4 mg/kg) decreases c-Fos expression by 58%[1].

GELSEMINE Preparation Products And Raw materials
Raw materials
Preparation Products
GELSEMINE Suppliers
Global(193)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29859
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
GELSEMINE Spectrum
509-15-9, GELSEMINERelated Search:
  • Alkaloids
  • standardized herbal extract
  • reference standards from Chinese medicinal herbs (TCM).
  • phytochemical
  • pharmaceutical intermediate
  • chemical reagent
  • 生物碱类
  • 抑制剂
  • 高端化学
  • 试剂
  • 标准品，对照品
  • 标准品 -中药标准品
  • 生物碱
  • 新品
  • 标准品-中药标准品
  • 分析试剂标准品
  • 植物提取物
  • 标准品
  • 中药对照品
  • 对照品
  • 植提标准品
  • C20H22N2O2
  • 钩吻碱,10 MM DMSO 溶液
  • 甲醇中钩吻碱溶液标准物质
  • 钩吻碱甲对照品
  • 钩吻碱甲标准品
  • (3S,3AS,3'S,5R,8AS,9R)-1-甲基-3-乙烯基-1,2,3,3A,5,7,8,8A-八氢螺[3,8,5-(EPIETHANE[1,1,2]三基)OXEPINO[4,5-B]吡咯-4,3'-吲哚]-2'-酮
  • 胶胺
  • 钩吻碱(甄准不供应)
  • 钩吻碱甲
  • 常绿黄素馨碱、钩吻素甲、钩吻碱甲
  • 钩吻素碱
  • 钩吻碱对照品,
  • 钩吻素甲(钩吻碱)
  • 钩吻碱:钩吻碱甲
  • 钩吻碱, 来源于胡蔓藤
  • 钩吻宁
  • GELSEMINE 钩吻素甲
  • 钩吻碱(钩吻素甲,钩吻碱钾,胡曼鹼,常绿黄素馨碱)
  • 钩吻素甲(标准品)
  • 钩吻素甲,钩吻碱钾,胡曼鹼,常绿黄素馨碱
  • 胡曼鹼
  • 钩吻碱
  • 钩吻碱钾
  • 钩吻素甲
  • 常绿黄素馨碱
  • 509-15-9
  • Gelsemine, 10 mM in DMSO
  • Gelsemine-RM
  • Gelsemine in methanol
  • (3S,3aR,3'S,5R,8S,8aS,9R)-1-methyl-3-vinyl-1,2,3,3a,5,7,8,8a-octahydrospiro[3,8,5-(epiethane[1,1,2]triyl)oxepino[4,5-b]pyrrole-4,3'-indolin]-2'-one
  • (+)-Gelsemine
  • (3S,3aS,3'S,5R,8aS,9R)-1-Methyl-3-vinyl-1,2,3,3a,5,7,8,8a-octahydrospiro[3,8,5-(epiethane[1,1,2]triyl)oxepino[4,5-b]pyrrole-4,3'-indolin]-2'-one
  • (3S,3aS,3'S,8S,8aS)-1-methyl-3-vinyl-1,2,3,3a,5,7,8,8a-octahydrospiro[3,8,5-(epiethane[1,1,2]triyl)oxepino[4,5-b]pyrrole-4,3'-indolin]-2'-one
  • Gelsemine, 98%, from Gelsemium elegans (Gardner & Chapm.) Benth.
  • Spiro[3,5,8-ethanylylidene-1H-pyrano[3,4-c]pyridine-10,3'-[3H]indol]-2'(1'H)-one,5-ethenyl-3,4,4a,5,6,7,8,8a-octahydro-7-Methyl-, (3R,3'S,4aR,5S,8S,8aS,9S)-
  • GESEMINE
  • GELSEMINE

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