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VASICINONE

VASICINONE Structure
VASICINONE
  • CAS No.486-64-6
  • Chemical Name:VASICINONE
  • CBNumber:CB4385271
  • Molecular Formula:C11H10N2O2
  • Formula Weight:202.21
  • MOL File:486-64-6.mol
VASICINONE Property
  • Melting point 200-202℃
  • Boiling point 320.7°C (rough estimate)
  • Density 1.50
  • refractive index 1.5300 (estimate)
  • storage temp. 2-8°C
  • solubility Soluble in chloroform and ethanol;
  • form powder
  • pka 12.76±0.20(Predicted)
  • color White
  • Water Solubility 1.597g/L(25 ºC)
  • FDA UNII G6T5819NXM
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P501-P270-P264-P301+P312+P330

VASICINONE Chemical Properties,Usage,Production

  • Description A further alkaloid present in Adhatoda vasica and Peganum harmala, this base forms colourless crystals from 95 per cent EtOH. It has [α]22D - 100° (c 0.5, CHCL3) and the ultraviolet spectrum has absorption maxima at 227, 272, 302 and 315 mfJ.. The alkaloid yields a series of crystalline salts with mineral acids, e.g. the hydrochloride, m.p. 232-4°C; hydro bromide, m.p. 254-5°C (dec.); hydriodide, m.p. 222-6°C (dec.); nitrate, m.p. 138-9° C (dec.) and the sulphate, m.p. l82-5°C (dec.). The optically inactive form of the base has been prepared synthetically, m.p. 211- 2°C. The alkaloid is an active bronchodilator.
  • Uses Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders[1].
  • Definition ChEBI: Vasicinone is a member of quinazolines.
  • target P450 (e.g. CYP17)
  • References Ghose et al., J. Chem. Soc., 2740 (1932)
    Morris, Horford, Adams., J. Amer. Chem. Soc., 57,951 (1935)
    Mehta, Naravane, Desai., J. Org. Chem., 28, 445 (1963)
VASICINONE Preparation Products And Raw materials
Raw materials
Preparation Products
VASICINONE Suppliers
Global(102)Suppliers
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VASICINONE Spectrum
486-64-6, VASICINONERelated Search:
  • Alkaloids
  • 抑制剂
  • 化工原料
  • 标准品 -对照药材
  • 生物碱
  • 对照品
  • 分析试剂标准品
  • 植物提取物
  • 标准品
  • Cl1H10N2O2
  • 鸭嘴花碱酮,10 MM DMSO 溶液
  • VASICIN酮(P)
  • 486-64-6
  • Vasicinone, 10 mM in DMSO
  • Vasicinone-RM
  • Pyrrolo[2,1-b]quinazolin-9(1H)-one,2,3-dihydro-3-hydroxy-, (3S)-
  • l-Vasicinone
  • 2,3-Dihydro-3-hydroxypyrrolo[2,1-b]quinazolin-9(1H)-one
  • (3R)-2,3-Dihydro-3β-hydroxypyrrolo[2,1-b]quinazoline-9(1H)-one
  • (3R)-2,3-Dihydro-3-hydroxypyrrolo[2,1-b]quinazolin-9(1H)-one
  • VASICINONE

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