ChemicalBook > CAS DataBase List > BETA-ACETYLDIGOXIN

BETA-ACETYLDIGOXIN

BETA-ACETYLDIGOXIN Structure
BETA-ACETYLDIGOXIN
  • CAS No.5355-48-6
  • Chemical Name:BETA-ACETYLDIGOXIN
  • CBNumber:CB4328012
  • Molecular Formula:C43H66O15
  • Formula Weight:822.98
  • MOL File:5355-48-6.mol
BETA-ACETYLDIGOXIN Property
  • Melting point 271-273°C
  • alpha D20 +30.4° (c = 1.2 in alc)
  • Boiling point 681.03°C (rough estimate)
  • Density 1.1139 (rough estimate)
  • refractive index 1.5940 (estimate)
  • storage temp. -20°C Freezer
  • solubility Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in ethanol (96 per cent).
  • pka 13.41±0.70(Predicted)
  • FDA UNII P7K44M64CW
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • RIDADR  :3249
  • HazardClass  :6.1(a)
  • PackingGroup  :II
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300+H330
  • Precautionary statements P260-P301+P330+P331+P310-P304+P340+P310-P403+P233

BETA-ACETYLDIGOXIN Chemical Properties,Usage,Production

  • Chemical Properties White Solid
  • Originator Novodigal ,Asta Medica Arzneimittel
  • Uses Digoxin derivative, a cardiotonic glycosides
  • Definition ChEBI: Acetyldigoxin is a cardenolide glycoside.
  • Manufacturing Process Dried crude product of the partial acetylation of digoxin (42 g) prepared from digitalis - is dissolved under reflux in acetone (480 ml) and n-hexane (2400 ml) is added to the solution with stirring. Fine crystals, which begin to separate immediately, are left at room temperature for 5 hours, then they are filtered with suction, washed with n-hexane and dried in vacuum at 40°C, yielding 32 g of crude β-acetyldigoxin (product 1). Product 1 (31 g) is dissolved under reflux in chloroform (500 ml) and toluene (2500 ml) is added thereto with stirring. The crystals, which separate after standing for 6 hours at room temperature, are filtered, washed with toluene and ether and dried in vacuum yielding 29 g of β-acetyldigoxin (product 2). MP: 249°-251°C.
    The filtrate, which results from the separation of product 1, is evaparated to dryness in vacuum. The residue, which mainly contains unreacted digoxin, is purified by recrystallization from pyridine/ether/water (3.5:5:40) and repeatedly acetylated. It can then be recycled to produce more β- acetyldigoxin. The filtrate resulting from the separation of product 2 is evaporated to dryness. The resulting residue contains the di- and polyacetyl derivatives of digoxin, which are deacetylated to digoxin in a known manner and later is returned to a further acetylation process and can then be recycled to produce more β-acetyldigoxin. Beta-Acetyldigoxin may be prepared from digoxin, acetic acid and dicyclohexylcarbodiimide using the last one as a condensing agent.
  • Therapeutic Function Cardiotonic
BETA-ACETYLDIGOXIN Preparation Products And Raw materials
Raw materials
Preparation Products
BETA-ACETYLDIGOXIN Suppliers
Global(45)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    AFINE CHEMICALS LIMITED
  • Tel：+86-0571-85134551
  • Email：sales@afinechem.com
  • Country：China
  • ProdList：15349
  • Advantage：58
  • Supplier：
    GIHI CHEMICALS CO.,LIMITED
  • Tel： +8618058761490
  • Email：info@gihichemicals.com
  • Country：China
  • ProdList：49984
  • Advantage：58
  • Supplier： J & K SCIENTIFIC LTD.
  • Tel： 18210857532
  • Email：jkinfo@jkchemical.com
  • Country：China
  • ProdList：96815
  • Advantage：76
BETA-ACETYLDIGOXIN Spectrum
5355-48-6, BETA-ACETYLDIGOXINRelated Search:
  • Steroids
  • Pharmaceuticals
  • Oligosaccharides
  • Intermediates & Fine Chemicals
  • 杂质对照品
  • 标准品
  • 地高辛
  • 地高辛杂质
  • -乙酰地高辛/A1A
  • (2R,3S,4S,6S)-6-(((2R,3S,4S,6S)-6-(((2R,3S,4S,6R)-6-(((3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-二羟基-10,13-二甲基-17-(5-氧基-2,5-二氢呋喃-3-基)十六氢-1H-环戊烷[A]菲-3-基)氧基)-4-羟基-2-甲基四氢呋喃-2H-吡喃-3-基)氧基)-4-羟基-2-甲基四氢-2H-吡喃-3-基)氧基)-4-羟基-2-甲基四氢-2H-吡喃-3-基)氧基)-4-羟基- 2-甲基四氢-2H-吡喃-3-乙酸酯(地高辛杂质)
  • 醋地高辛
  • -乙酰地高辛峰鉴别 EP标准品
  • -乙酰地高辛 EP标准品
  • 地高辛EP杂质J
  • 地高辛杂质J(EP)
  • B-乙酰地高辛
  • 地高辛杂质J
  • 5355-48-6
  • β-Acetyldigoxin for peak identification
  • (2R,3S,4S,6S)-6-(((2R,3S,4S,6S)-6-(((2R,3S,4S,6R)-6-(((3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-Dihydroxy-10,13-dimethyl-17-(5-oxo-2,5-dihydrofuran-3-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate (Digoxin Impurity)
  • D.?(2R)-2-(acetylamino)-3-(acetylsulfanyl)propanoicacid(N,S-diacetyl-l-cysteine).
  • 3β-[(4-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12β,14-dihydroxy-5β-card-20(22)-enolide (β-acetyldigoxin),
  • 2-Acetyl Digoxin
  • Digoxin EP Impurity J
  • Digoxin Impurity 10(Digoxin EP Impurity J)
  • -acetyldigoxin for peak identification CRS
  • -Acetyldigoxin CRS
  • Card-20(22)-enolide, 3-[(O-4-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
  • BETA-ACETYLDIGOXIN USP/EP/BP
  • β-Acetyl Digoxin
  • hexamethyleneimine3,5-dinitrobenzoate
  • digoxin,4’’’-acetate
  • digoxigenin+zuckerkettewiebeiacetyl-digitoxin-alpha
  • digoridb
  • acetyl-digoxin-beta
  • acetate,beta-digoxi
  • Digoxin IMpurity J
  • (3β,5β,12β)-3-[(O-4-O-Αcetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(14)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(14)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
  • Acetyldigoxin research grade
  • Digotab
  • Cor-puren
  • Cardioreg
  • Card-20(22)-enolide, 3-((o-4-o-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1.4)-o-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1.4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)-
  • 3β-[4-O-[4-O-(4-O-Acetyl 2,6-dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyloxy]-12β,14-dihydroxy-5β,14β-carda-20(22)-enolide
  • 3β-[[4-O-[4-O-(4-O-Acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-12β,14-dihydroxy-5β-card-20(22)-enolide
  • Card-20(22)-enolide, 3-[(O-4-O-acetyl-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1->4)-O-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-d-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3beta,5beta,12beta)-
  • 4’’’-acetyldigoxin
  • 16’-acetyldigoxin
  • B-ACETYLDIGOXIN
  • BETA-ACETYLDIGOXIN
  • ACETYLDIGOXIN, B-
  • novodigal

Home

My