Description
A series of 2,5-
phenethylamines, collectively referred to as 2Cs, have psychoactive effects. The most effective 2C compounds are 2,5-
dimethoxy-
4-
substituted phenethylamines; many are scheduled as illegal substances. 2C-
H is described formally as 2,5-
dimethoxyphenethylamine. Unlike the 4-
substituted 2-
C forms, it has little effect on serotonin receptors, activating the 5-
HT
2C receptor to 20% that induced by serotonin (pEC
50 = 5.93). This product is intended for research and forensic applications.
Uses
A series of 2,5-phenethylamines, collectively referred to as 2Cs, have psychoactive effects. The most effective 2C compounds are 2,5-dimethoxy-4-substituted phenethylamines; many are scheduled as ille
gal substances. This product is intended for research and forensic applications.
Synthesis
2,5-dimethoxybenzaldehyde 3.32 g (0.02 mol), ammonium acetate 0.5 g and 4 mL of nitromethane were put into a reaction flask together, heated to 85 C with stirring, kept warm for 30 min, poured the reaction product into cold water while it was still hot, cooled, and yellow crystals were precipitated, filtered, and washed with 70% of ethanol to obtain 2,5-dimethoxy--nitroaniline 3.7 g (Yield 90%).
2,5-dimethoxy--nitrostyrene 4.18g added to 250mL three-necked flask, add 95% ethanol 20mL, stirring, heated to 40 , add concentrated hydrochloric acid 35mL, water 40mL; at 65 in batches to add 25g of zinc powder, adding a small amount of zinc powder after adding a small amount of metal mercury, keep the temperature between 65 ~ 70 ; add zinc powder than, reduce the temperature to 50 to join the Hydrochloric acid 10mL, maintain 50 ~ 55 3h; cooling, add sodium carbonate pH8 ~ 9, extracted with n-butanol, extract distillation under reduced pressure to remove n-butanol, the reaction into a dark brown slurry, weighing 6.5g. into the salt: to the slurry reactant to add methanol hydrochloric acid solution, evaporate most of the methanol, cooling precipitation, get light brown crystals of 2,5-dimethoxy--nitrophenethylene, 2.52g (yield 60%).
