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HYDROXYFLUTAMIDE

HYDROXYFLUTAMIDE Structure
HYDROXYFLUTAMIDE
  • CAS No.52806-53-8
  • Chemical Name:HYDROXYFLUTAMIDE
  • CBNumber:CB4307190
  • Molecular Formula:C11H11F3N2O4
  • Formula Weight:292.21
  • MOL File:52806-53-8.mol
HYDROXYFLUTAMIDE Property
  • Melting point 125-130°C
  • Boiling point 443.8±45.0 °C(Predicted)
  • Density 1.472
  • storage temp. room temp
  • solubility DMSO: >10mg/mL
  • pka 12.87±0.70(Predicted)
  • form powder
  • color white to tan
  • EWG's Food Scores 1
  • FDA UNII 31D90UKP5Y
  • UNSPSC Code 51111800
  • NACRES NA.77
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26-36/37/39
  • WGK Germany  :3
  • RTECS  :TX1466250
  • HS Code  :2924297099
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338
HYDROXYFLUTAMIDE Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: H4166
  • Product name : Hydroxyflutamide
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹14516.33
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: H4166
  • Product name : Hydroxyflutamide
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹56430.73
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: H1600
  • Product name : Hydroxyflutamide
  • Purity: 
  • Packaging: 25MG
  • Price: ₹9800
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: H1600
  • Product name : Hydroxyflutamide
  • Purity: 
  • Packaging: 100MG
  • Price: ₹19600
  • Updated: 2022/05/26
  • Buy: Buy

HYDROXYFLUTAMIDE Chemical Properties,Usage,Production

  • Description 2-hydroxy Flutamide is the major metabolite formed during the metabolism of the non-steroidal antiandrogen flutamide by cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4. Through competitive inhibition of the binding of testosterone to the nuclear androgen receptor (AR; IC50 = ~300-900), 2-hydroxy flutamide blocks the expression of AR target genes and prevents androgen-dependent stabilization of the AR. Compared to flutamide, 2-hydroxy flutamide is a more potent antiandrogen in vivo, demonstrating a higher binding affinity for the AR (0.1% binding affinity relative to dihydrotestosterone) and, thus, is the predominant contributor to the therapeutic effects of flutamide in the treatment of prostate cancer.
  • Chemical Properties HYDROXYFLUTAMIDE is Yellow-Brown Powder
  • Uses HYDROXYFLUTAMIDE is used non-steroidal antagonist Flutamide. Shown to be an antianhydrogen.
  • Uses The active metabolite of the widely used non-steroidal antagonist Flutamide (F598850). Shown to be an antianhydrogen.
  • Uses Shown to be an antianhydrogen. The active metabolite of the widely used non-steroidal antagonist flutamide
  • Biochem/physiol Actions Hydroxyflutamide plays a role in preventing the binding of 5α-dihydrotestosterone (DHT) and testosterone to the androgen receptors.
  • References [1] kolvenbag g, furr b j a, blackledge g r p. receptor affinity and potency of non-steroidal antiandrogens: translation of preclinical findings into clinical activity[j]. prostate cancer and prostatic diseases, 1998, 1: 307-314.
    [2] heinlein c a, chang c. androgen receptor in prostate cancer[j]. endocrine reviews, 2004, 25(2): 276-308.
    [3] shet m s, mcphaul m, fisher c w, et al. metabolism of the antiandrogenic drug (flutamide) by human cyp1a2[j]. drug metabolism and disposition, 1997, 25(11): 1298-1303.
    [4] gao w, kim j, dalton j t. pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands[j]. pharmaceutical research, 2006, 23(8): 1641-1658.
HYDROXYFLUTAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
HYDROXYFLUTAMIDE Suppliers
Global(147)Suppliers
  • Supplier：
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    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
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HYDROXYFLUTAMIDE Spectrum
52806-53-8, HYDROXYFLUTAMIDERelated Search:
  • Metabolites
  • Inhibitors
  • Various Metabolites and Impurities
  • Pharmaceuticals
  • Metabolites & Impurities
  • Intermediates & Fine Chemicals
  • Aromatics
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  • 52806-53-8
  • 2-hydroxy Flutamide, 10 mM in DMSO
  • Inhibitor,inhibit,prostate cancer,HFT,Flutamide,2 hydroxy Flutamide,2hydroxy Flutamide,Androgen Receptor,Hydroxyflutamide
  • 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]prop
  • 2-Hydroxyflutamide (Hydroxyniphtholide)
  • Flutamide Impurity 7
  • 2-Hydroxy-4'-nitro-3'-(trifluoromethyl)isobutyranilide
  • Flutamide Hydroxy Impurity
  • utamide
  • Hydroxy FL
  • 2-Hydroxy-2-methyl-N-[4-nitro-3-(tr
  • CS-1970
  • 2-HYDROXY-FLUTAMIDE
  • 2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]-PROPANAMIDE
  • HYDROXYFLUTAMIDE
  • Propanamide, 2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-
  • alpha,alpha,alpha-Trifluoro-2-methyl-4'-nitro-m-lactotoluidide
  • Sch-16423
  • N-[3-(Trifluoromethyl)-4-nitrophenyl]-2-hydroxyisobutyramide
  • Hydroxyflutamid
  • 2-Hydroxy-2-methyl-N-(3-trifluoromethyl-4-nitrophenyl)propanamide
  • Hydroxyflutamide, >=98%
  • a,a,a-Trifluoro-2-methyl-4′-nitro-m-lactotoluidide
  • HydroxyflutaMide (Hydroxyniphtholide)
  • α,α,α-Trifluoro-2-Methyl-4'-nitro-M- lactotoluidide
  • HYDROXYFLUTAMIDE (2-HYDROXY-2-METHYL-N-{4''-NITRO-3''-(TRIFLUOROMETHYL)PHENYL}PROPANAMIDE)
  • 5-HYDROXYFLUTAMIDE
  • 5-Hydroxyflutamide, 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide,
  • Hydroxy-Flutamide(Flutamide metabolite)
  • 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propionamide
  • hydroxyniphtholide
  • 2-hydroxy-2-methyl-n-(4-nitro-3-(trifluoromethyl)phenyl)-propanamid

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