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LY-2795050

LY-2795050 Structure
LY-2795050
  • CAS No.1346133-08-1
  • Chemical Name:LY-2795050
  • CBNumber:CB42666653
  • Molecular Formula:C23H22ClN3O2
  • Formula Weight:407.89
  • MOL File:1346133-08-1.mol
LY-2795050 Property
  • Boiling point 532.4±50.0 °C(Predicted)
  • Density 1.287±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO : 50 mg/mL (122.58 mM; Need ultrasonic)
  • form Powder
  • pka 15.57±0.50(Predicted)
  • color White to off-white
  • FDA UNII 71PAL357HO
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

LY-2795050 Chemical Properties,Usage,Production

  • Uses LY2795050 is a short-acting selective κ(kappa)-opioid receptor (KOR) antagonist. LY2795050 has high affinity for the KOR with Ki value of 0.72 nM. LY2795050 can be used for the research of central nervous system dysfunction[1][2].
  • in vivo

    LY2795050 (i.p., 0.032-0.1mg/kg, 30 min) prevents dose-dependent grooming deficits produced by U50,488 in male and female mice[2].
    LY2795050 (i.p., 0.032-0.1mg/kg, 0-150 min) has sexual dimorphism in some behavioral effects[2].

    Animal Model:C57BL/6J mice[2]
    (gonadally intact, adult, male and female)
    Dosage:0.032-0.1 mg/kg
    Administration:i.p., 0.032-0.1mg/kg, 30 min
    Result:Could dose-dependently prevent the self-grooming deficits caused by U50,488 with a 30-min pre-treatment.
    Not effected in blocking the effects of U50,488 with smaller dose (0.032mg/kg) in either males or females.
    Decreased immobility in the FST in males at a dose of 0.1mg/kg, but not in females, up to a dose of 0.32mg/kg.
    Prevented and also reversed (at 0.32mg/kg) the locomotor-depressant effects of U50,488 (10mg/kg), in males and females.
  • References [1] Ming-Qiang Zheng, et al. Synthesis and evaluation of 11C-LY2795050 as a κ-opioid receptor antagonist radiotracer for PET imaging. J Nucl Med DOI:10.2967/jnumed.112.109512
    [2] Eduardo R Butelman, et al. Profile of a short-acting κ-antagonist, LY2795050, on self-grooming behaviors, forced swim test and locomotor activity: sex comparison in mice. J Psychopharmacol. 2021 May;35(5):579-590. DOI:10.1177/0269881121996883
LY-2795050 Preparation Products And Raw materials
Raw materials
Preparation Products
LY-2795050 Suppliers
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LY-2795050 Spectrum
  • 抑制剂
  • G蛋白偶联受体&G蛋白
  • 化合物LY2795050,10 MM DMSO 溶液
  • 化合物LY2795050
  • LY2795050(S型)
  • 1346133-08-1
  • LY2795050, 10 mM in DMSO
  • 3-chloro-4-(4-{[(2S)-2-(pyridin-3-yl)pyrrolidin-1-yl]methyl}phenoxy)benzamide
  • LY2795050,Inhibitor,central nervous system dysfunction,sex differences,inhibit,Opioid Receptor,κκ-receptor,LY-2795050,LY 2795050
  • Benzamide, 3-chloro-4-[4-[[(2S)-2-(3-pyridinyl)-1-pyrrolidinyl]methyl]phenoxy]-
  • LY 2795050; LY-2795050
  • LY2795050;LY 2795050;LY-2795050;1346133-08-1
  • (S)-3-chloro-4-(4-((2-(pyridin-3-yl)pyrrolidin-1-yl)methyl)phenoxy)benzamide
  • LY-2795050
  • LY2795050
  • LY 2795050
  • 3-chloro-4-[4-[ [ (2S)-2-(3-pyridyl)pyrrolidin-1-yl]methyl]phenoxy]benzamide

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