Description
Secobarbital (CRM) (Item No. 21707) is a certified reference material categorized as a barbiturate. It extends intoxication and increases withdrawal effects in patients with a family history of alcoholism. Secobarbital is regulated as a Schedule II compound in the United States. Secobarbital (CRM) (Item No. 21707) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
Uses
Barbiturates are being widely used as antiepileptics, hypnotics, and anesthetics
Controlled substance.
Definition
ChEBI: A member of the class of barbiturates that is barbituric acid in which the hydrogens at position 5 are substituted by prop-2-en-1-yl and pentan-2-yl groups.
brand name
Seconal(Lilly);Seconal sodium;Tuinal.
World Health Organization (WHO)
Secobarbital is a short to intermediate-acting barbiturate which is
controlled under Schedule III of the 1971 Convention on Psychotropic Substances.
See WHO comment for barbiturates.
(Reference: (UNCPS3) United Nations Convention on Psychotropic Substances (III),
, , 1971)
Purification Methods
It is purified by dissolving the sodium salt [309-43-3] in 10% HCl which precipitates the acid form that is extracted into Et2O. The extract is dried (Na2SO4) and evaporated. The residue is then purified by repeated crystallisation from CHCl3. [Buchet & Sandorfy J Phys Chem 88 3274 1984, Beilstein 24 III/IV 2013.]
References
[1] MARY E. MCCAUL. Alcohol and Secobarbital Effects as a Function of Familial Alcoholism: Extended Intoxication and Increased Withdrawal Effects[J]. Alcohol (Hanover, York County, Pa.), 1991, 15 1: 94-101. DOI:
10.1111/j.1530-0277.1991.tb00524.x
