IRISQUINONE
- Product NameIRISQUINONE
- CAS56495-82-0
- CBNumberCB4184933
- MFC24H38O3
- MW374.56
- MDL NumberMFCD01734461
- MOL File56495-82-0.mol
Chemical Properties
| Melting point: | 40-43 °C |
| Boiling point: | 483.4±34.0 °C(Predicted) |
| Density | 0.97±0.1 g/cm3(Predicted) |
| LogP | 8.850 (est) |
IRISQUINONE Chemical Properties,Usage,Production
Uses
Irisquinone, a natural product, is an anticancer agent. Irisquinone is also a radiation sensitizer for cancer. Irisquinone reduces GSH level and inhibits the repair of DNA singular strand breaks[1][2][3].in vivo
Irisquinone (12.5 mg/kg, perfused daily) makes the rabbit VX2 lung transplant tumor wall thinner and the necrotic area larger in the irisquinone + radiotherapy group[1].
| Animal Model: | Rabbit bearing VX2 lung transplant tumor[1] |
| Dosage: | 12.5 mg/kg |
| Administration: | Perfused daily, starting from 3 days before irradiation to the end of irradiation. |
| Result: | Displayed no significant difference of tumor growth between the radio therapy and Irisquinone + radiotherapy groups. Showed thinner tumor wall and the larger necrotic area in the Irisquinone + radiotherapy group. |
References
[1] Xu H, et al. Dynamic observation of the radiosensitive effect of irisquinone on rabbit VX2 lung transplant tumors by using fluorine-18-deoxyglucose positron emission tomography/computed tomography. Nucl Med Commun. 2013 Mar;34(3):220-8. DOI:10.1097/MNM.0b013e32835d3730[2] Wang H, et al. Radiosensitizing effect of irisquinone on glioma through the downregulation of HIF-1α evaluated by 18F-FDG and 18F-FMISO PET/CT. Nucl Med Commun. 2016 Jul;37(7):705-14. DOI:10.1097/MNM.0000000000000498
[3] Liang, l., et al. The effect of Irisquinone on the glutathione system and MRP expression of cisplatin-resistant human lung adenocarcinoma cell line (A DDP549). Chin J Cancer Res 13, 171–175 (2001).
IRISQUINONE Suppliers
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