Uses
2,3,4,5,6-Pentafluorobenzyl alcohol was used in the synthesis of pentafluorobenzyloxy substituted metal-free phthalocyanine.
Definition
ChEBI: An organofluorine compound that is benzyl alcohol substituted by fluoro groups at positions 2, 3, 4, 5 and 6.
General Description
Structures of complex of horse liver alchohol dehydrogenase enzyme with 2,3,4,5,6-pentafluorobenzyl alcohol has been investigated by X-ray crystallography.
Synthesis
General procedure for the synthesis of pentafluorobenzyl alcohol from pentafluorobenzaldehyde: A mixture of pentafluorobenzaldehyde (1.5 mmol), catalyst (0.01 mmol), and isopropanol (18.5 mL) was stirred for 10 minutes at 82 °C. Subsequently, 1.5 mL of 0.1 M KOH (0.15 mmol) solution was added to the mixture. The reaction mixture was stirred continuously at reflux temperature. During the reaction, aliquots were periodically removed from the reaction vessel and the reaction progress was monitored by gas chromatography (GC) and hydrogen nuclear magnetic resonance (1H NMR). The yield of the final product was the average of two independent experiments.
References
[1] Journal of Organometallic Chemistry, 2016, vol. 807, p. 36 - 44
[2] Dalton Transactions, 2015, vol. 44, # 41, p. 18237 - 18246
[3] Journal of the American Chemical Society, 2014, vol. 136, # 45, p. 15813 - 15816
[4] Steroids, 2011, vol. 76, # 10-11, p. 1136 - 1140
[5] Journal of the Chemical Society, 1961, p. 808 - 817
