ChemicalBook > CAS DataBase List > 2-CHLORO-4-PHENYLQUINAZOLINE
2-CHLORO-4-PHENYLQUINAZOLINE
2-CHLORO-4-PHENYLQUINAZOLINE
- CAS No.29874-83-7
- Chemical Name:2-CHLORO-4-PHENYLQUINAZOLINE
- CBNumber:CB41490329
- Molecular Formula:C14H9ClN2
- Formula Weight:240.69
- MOL File:29874-83-7.mol
2-CHLORO-4-PHENYLQUINAZOLINE Property
- Melting point 113.0 to 117.0 °C
- Boiling point 347.4±30.0 °C(Predicted)
- Density 1.285±0.06 g/cm3(Predicted)
- storage temp. under inert gas (nitrogen or Argon) at 2-8°C
- form powder to crystal
- pka 0.24±0.30(Predicted)
- color White to Orange to Green
Safety
- HS Code :2933998090
-
Symbol(GHS)
- Signal wordWarning
- Hazard statements H302
- Precautionary statements P280-P305+P351+P338
2-CHLORO-4-PHENYLQUINAZOLINE Price
More Price(2)
- Brand: TCI Chemicals (India)
- Product number: C3173
- Product name : 2-Chloro-4-phenylquinazoline
- Purity: min. 98.0 %
- Packaging: 1G
- Price: ₹7300
- Updated: 2022/05/26
- Buy: Buy
- Brand: TCI Chemicals (India)
- Product number: C3173
- Product name : 2-Chloro-4-phenylquinazoline
- Purity: min. 98.0 %
- Packaging: 5G
- Price: ₹19500
- Updated: 2022/05/26
- Buy: Buy
2-CHLORO-4-PHENYLQUINAZOLINE Chemical Properties,Usage,Production
- Uses 2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators.
- Uses 2-CHLORO-4-PHENYLQUINAZOLINE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
- Uses 2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators.
-
Synthesis
A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ?? C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield).
2-CHLORO-4-PHENYLQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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