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Xanomeline

Xanomeline Structure
Xanomeline
  • CAS No.131986-45-3
  • Chemical Name:Xanomeline
  • CBNumber:CB4144966
  • Molecular Formula:C14H23N3OS
  • Formula Weight:281.42
  • MOL File:131986-45-3.mol
Xanomeline Property
  • Boiling point 397.0±42.0 °C(Predicted)
  • Density 1.101±0.06 g/cm3(Predicted)
  • storage temp. Sealed in dry,2-8°C
  • solubility H2O: soluble10mg/mL, clear (warmed)
  • form powder
  • pka 7.34±0.40(Predicted)
  • color off-white
  • InChIKey JOLJIIDDOBNFHW-UHFFFAOYSA-N
  • FDA UNII 9ORI6L73CJ
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301
  • Precautionary statements P264-P270-P301+P312-P330
Xanomeline Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: X2754
  • Product name : Xanomeline L-tartrate hydrate
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹103432.88
  • Updated: 2022/06/14
  • Buy: Buy

Xanomeline Chemical Properties,Usage,Production

  • Description Xanomeline is used as a potent and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist to increase neuronal excitability. Xanomeline is used in studies of neurological disorders such as Alzheimer's disease and schizophrenia. However, development of the drug was halted due to severe cholinergic adverse effects. Currently, xanomeline-trospium (KarXT) (a peripheral cholinergic antagonist) has been explored for the treatment of schizophrenia and a New Drug Application has been filed with the FDA, with a decision on whether it will be approved or not expected on 26 September 2024.
  • Uses Alzheimer’s disease treatment (cholinergic agonist).
  • Definition ChEBI: Xanomeline is a member of thiadiazoles and a tetrahydropyridine. It has a role as a muscarinic agonist and a serotonergic agonist.
  • Mechanism of action Xanomeline's mechanism of action is is to rebalance key neurotransmitter circuits, including acetylcholine, dopamine and glutamate, which are disrupted in schizophrenia and related disorders.
  • in vivo

    Xanomeline (0.5~3 mg/kg; s.c.; 1~3 hours) induces salivation and vomiting in some monkeys[3].
    Xanomeline shows functional dopamine antagonism and an antipsychotic-like profile. Xanomeline inhibits D-amphetamine- and ( )-apomorphine-induced behavior and do not cause extrapyramidal side effects[3].

    Animal Model:Male Cebus apella monkeys
    Dosage:0.5~3 mg/kg
    Administration:S.c.; 1~3 hours
    Result:Induced salivation and vomiting in some monkeys.
  • IC 50 mAChR1; mAChR4
Xanomeline Preparation Products And Raw materials
Raw materials
Preparation Products
Xanomeline Suppliers
Global(117)Suppliers
  • Supplier：
    Alchem Pharmtech,Inc.
  • Tel：8485655694
  • Email：sales@alchempharmtech.com
  • Country：United States
  • ProdList：63687
  • Advantage：58
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    Finetech Industry Limited
  • Tel：+86-27-8746-5837<br/>+8619945049750
  • Email：info@finetechnology-ind.com
  • Country：China
  • ProdList：9642
  • Advantage：58
Xanomeline Spectrum
131986-45-3, XanomelineRelated Search:
  • API
  • 高纯试剂
  • 原料药
  • 精神类原料药
  • 抑制剂
  • 化学试剂
  • 医药原料
  • 药物
  • 拟胆碱药和抗胆碱药
  • C14H23N3OS
  • 沙诺美林
  • 呱诺美林
  • 占诺美林,10 MM DMSO 溶液
  • 占诺美林酒石酸盐
  • 3-(己基氧基)-4-(1-甲基-1,2,5,6-四氢-3-吡啶基)-1,2,5-噻二唑
  • 占诺美林 XANOMELINE
  • 占诺美林 XANOMELINE LY-246708
  • 占诺美林, 5-[4-(己基氧基)-1,2,5-硫杂二氮杂环戊熳-3-基]-1-甲基-1,2,3,6-四氢吡啶
  • 5-[4-(己基氧基)-1,2,5-硫杂二氮杂环戊熳-3-基]-1-甲基-1,2,3,6-四氢吡啶
  • 咕诺美林
  • 噻诺美林
  • 3-(己氧基)-4-(1-甲基-1,2,5,6-四氢吡啶-3-基)-1,2,5-噻二唑
  • 占诺美林
  • 3-[4-(己基氧)-1,2,5-噻二唑-3-基]-1,2,5,6-四氢-1-甲基吡啶
  • 呫诺美林
  • 131986-45-3
  • Xanomeline, 10 mM in DMSO
  • 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-1,2,5-thiadiazole
  • Xanomeline(LY-246708)
  • XANOMELINE
  • 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE USP/EP/BP
  • Xanomeline L-tartrate hydrate >=98% (HPLC)
  • Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-
  • 3-Hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole
  • -4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)
  • 3-(Hexyloxy)
  • Xanomeline L-tartrate hydrate
  • 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole
  • NNC-11-0232
  • Memcor
  • LY-246708
  • Lomeron
  • 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE
  • 3-[4-(Hexy loxy)-1，2，5-thiadiazol-3-y1]-1，2，5，6-tetrahydro-1-methylpyridine

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