peptide 74

Description

Peptide 74 is a synthetic peptide that contains the sequence immediately upstream of the cleavage site of the 72-kDa type IV collagenase and other members of the matrix metalloproteinase family; inhibits the activated form of this enzyme.

Uses

Peptide 74 is a synthetic peptide containing the prodomain sequence of matrix metalloproteinase (MMP). Peptide 74 inhibits the activated form of the 72-kDa type IV collagenase in vitro[1].

Definition

Peptide 74 is a synthetic peptide that has gained attention in the field of biomedical research. It has demonstrated potential applications in various areas, including drug discovery, proteomics, and immunology. Peptide 74 shows promise as an inhibitor or activator of specific biological pathways or protein-protein interactions. As with any experimental compound, caution should be exercised when handling and using Peptide 74. Safety measures such as wearing appropriate protective equipment and following proper laboratory protocols are recommended. Storage guidelines typically involve keeping the peptide at low temperatures, such as -20°C or below, to maintain its stability and activity.

References

[1] A Melchiori, et al. Inhibition of tumor cell invasion by a highly conserved peptide sequence from the matrix metalloproteinase enzyme prosegment. Cancer Res. 1992 Apr 15;52(8):2353-6. PMID:1313744
[2] P P Lee, et al. Functional role of matrix metalloproteinases (MMPs) in mammary epithelial cell development. J Cell Physiol. 2001 Jul;188(1):75-88. DOI:10.1002/jcp.1090