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bruceine A

bruceine A Structure
bruceine A
  • CAS No.25514-31-2
  • Chemical Name:bruceine A
  • CBNumber:CB41382240
  • Molecular Formula:C26H34O11
  • Formula Weight:522.54
  • MOL File:25514-31-2.mol
bruceine A Property
  • Boiling point 712.6±60.0 °C(Predicted)
  • Density 1.43±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility insoluble in EtOH; insoluble in H2O; ≥5.23 mg/mL in DMSO with gentle warming
  • form Powder
  • pka 8.81±0.70(Predicted)
  • color White to off-white
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

bruceine A Chemical Properties,Usage,Production

  • Chemical Properties White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the fruit of bruce chinensis.
  • Uses Bruceantin A acts as an anti-babesial quassinoid, extracted from the fruits of Brucea javanica, also an effective anti-trypanosomal agent in vitro. Cytotoxic agent.
  • Definition ChEBI: Bruceine A is a quassinoid.
  • Biological Activity ic50: 7.7 nm against the parasitescanine babesiosis is a tick-borne disease caused by the intraerythrocytic apicomplexan parasites, babesia gibsoni and b. canis. clinical signs of b. gibsoni infection are anemia, fever, thrombocytopenia, splenomegaly, lymphadenopathy, and lethargy. bruceine a, a natural quassinoid compound extracted from the brucea javanica (l.) merr. dried fruits, was reported to have antibabesial activity.
  • Physiological effects Bruisein A has an effect of treating malignant tumor, antimalarial and anti-inflammatory.
  • in vitro bruceine a inhibited the in-vitro babesia gibsoni growth in canine erythrocytes at lower concentration compared with the antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nm [1].
  • in vivo oral administration of bruceine a at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog. an untreated dog developed typical acute babesiosis symptoms including high fever, severe anemia, and complete loss of appetite and movement. however, the two bruceine a-treated dogs maintained their healthy conditions throughout the experimental period of 4 weeks [1].
  • target Antifection | p65 | NF-kB | ROS
  • References [1] nakao r, mizukami c, kawamura y, subeki, bawm s, yamasaki m, maede y, matsuura h, nabeta k, nonaka n, oku y, katakura k. evaluation of efficacy of bruceine a, a natural quassinoid compound extracted from a medicinal plant, brucea javanica, for canine babesiosis. j vet med sci. 2009 jan;71(1):33-41.
bruceine A Preparation Products And Raw materials
Raw materials
Preparation Products
bruceine A Suppliers
Global(129)Suppliers
  • Supplier：
    career henan chemical co
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    TargetMol Chemicals Inc.
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  • Country：United States
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bruceine A Spectrum
25514-31-2, bruceine ARelated Search:
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  • C26H34O11
  • 鸦胆子素 A,10 MM DMSO 溶液
  • 鸦胆子素A,鸦胆子苦素A
  • 鸦胆子素A标准品
  • 鸦胆子素A对照品
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  • 25514-31-2
  • Bruceine A, 10 mM in DMSO
  • Brucein A
  • Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-(3-methyl-1-oxobutoxy)-2,16-dioxo-, methyl ester, (11β,12α,15β)-
  • NSC31616
  • Brucea javanica A
  • Bruceine A 25514-31-2
  • Bruceine A (Dihydrobrusatol
  • NSC 310616
  • Dihydrobrusatol
  • 13,20-Epoxy-3,11β,12α-trihydroxy-15β-(3-methyl-1-oxobutoxy)-2,16-dioxopicras-3-en-21-oic acid methyl ester
  • bruceine A

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