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carbomycin

carbomycin Structure
carbomycin
  • CAS No.4564-87-8
  • Chemical Name:carbomycin
  • CBNumber:CB41380701
  • Molecular Formula:C42H67NO16
  • Formula Weight:841.98
  • MOL File:4564-87-8.mol
carbomycin Property
  • Melting point 214°
  • alpha D25 -58.6° (chloroform)
  • Boiling point 769.45°C (rough estimate)
  • Density 1.1761 (rough estimate)
  • refractive index 1.6220 (estimate)
  • pka pKb 7.2(at 25℃)
  • FDA 21 CFR 556.110
  • FDA UNII 3952621T3O
Safety
  • Toxicity :LD50 i.v. in mice: 550 mg/kg (Tanner)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

carbomycin Chemical Properties,Usage,Production

  • Originator Magnamycin,Pfizer,US,1953
  • Uses Sixteen-membered-ring macrolite antibiotic complex similar to Leucomycin and Erythromycin, produced by Stroptomyces halstedii.
  • Definition An antibiotic isolated from products of Strepto- myces halstedii when grown in suitable media by the deep-culture method. It inhibits growth of certain gram-positive bacteria such as staphylo- cocci, pneumococci, and hemolytic streptococci.
  • Manufacturing Process A selected strain of Streptomyces halstedii was cultivated in an aqueous nutrient medium under aerobic conditions and the resulting broth containing carbomycin antibiotics was filtered. The solutions was extracted twice at pH 6.5 with one-quarter volume of methyl isobutyl ketone. The combined extracts were concentrated to one-tenth volume under vacuum, and the antibiotics were extracted into water adjusted to a pH of about 2 with sulfuric acid. After adjusting the separated aqueous solution to pH 6.5, the antibiotic was extracted into benzene and the solution was concentrated to a small volume. Addition of hexane resulted in the separation of a solid product containing the benzene complexes of carbomycin A and carbomycin B, present in the fermentation broth.
  • brand name Magnamycin (Pfizer).
  • Therapeutic Function Antibiotic
  • Safety Profile Poison by subcutaneous route. Moderately toxic by intravenous and intramuscular routes. When heated to decomposition it emits toxic fumes of NOx.
carbomycin Preparation Products And Raw materials
Raw materials
Preparation Products
carbomycin Suppliers
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carbomycin Spectrum
4564-87-8, carbomycinRelated Search:
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Heterocycles
  • Chiral Reagents
  • Amines
  • C42H67NO16
  • 化合物 T30742
  • 卡波霉素
  • 4564-87-8
  • Carbomycin DISCONTINUED
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  • NSC 55924
  • MagnaMycin
  • M 4209
  • DeltaMycin A4
  • CarboMycin A
  • (12S,13S)-9-Deoxy-12,13-epoxy-12,13-dihydro-9-oxoleucoMycin V 3-Acetate 4B-(3-Methylbutanoate)
  • Nsc51001
  • Magnamycin a
  • Aids-012086
  • Aids012086
  • 3-Methyl-butyric acid 6-{[(Z)-7-acetoxy-8-methoxy-3,12-dimethyl-5,13-dioxo-10-(2-oxo-ethyl)-4,17-dioxa-bicyclo[14.1.0]heptadec-14-en-9-yloxy]-dimethylamino-hydroxy-methyl-tetrahydro-pyran-3-yloxy}-4-hydroxy-2,4-dimethyl-tetrahydro-pyran-3-yl ester
  • carbomycin

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