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guanoxabenz

guanoxabenz Structure
guanoxabenz
  • CAS No.24047-25-4
  • Chemical Name:guanoxabenz
  • CBNumber:CB41368413
  • Molecular Formula:C8H8Cl2N4O
  • Formula Weight:247.084
  • MOL File:24047-25-4.mol
guanoxabenz Property
  • Boiling point 383.1±52.0 °C(Predicted)
  • Density 1.54±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility Soluble in DMSO
  • pka 12.30±0.70(Predicted)
  • FDA UNII P9HIK5V7WK
  • ATC code C02CC07
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

guanoxabenz Chemical Properties,Usage,Production

  • Originator Benezrial,Houde,France,1978
  • Uses Antihypertensive.
  • Definition ChEBI: Guanoxabenz is a dichlorobenzene.
  • Manufacturing Process 2N sodium hydroxide solution (5 ml) is added to a stirred suspension of Smethylisothiosemicarbazide hydroiodide (2.33 g) and hydroxylamine hydrochloride (0.70 g) in water (6 ml) and stirred for 48 hours. The solution is evaporated in vacuo to provide 1-amino-3-hydroxyguanidine. One-third of the residue is dissolved in 16 ml of ethanol and 2,6-dichlorobenzaldehyde (0.6 g) is added to this solution. The reaction mixture is then stirred for 48 hours. The solution is then evaporated in vacuo and the residue dissolved in ether (30 ml) and in hydrochloric acid (30 ml). The aqueous phase is rendered alkaline with 2N sodium carbonate solution and extracted with ether. The ether layer is dried with sodium sulfate and evaporated. The residue is dissolved in ether and excess dry hydrogen chloride is passed into the solution.
    The resultant mixture is evaporated in vacuo and the residue triturated with methylene chloride to afford a crude product. Recrystallization from ethanolether (1:3) provides 1-(2,6-dichlorobenzylideneamino)-3-hydroxyguanidine hydrochloride; MP 173°C to 175°C. When the above process is carried out and S-benzylisothiosemicarbazide hydroiodide is used in place of S-methylisothiosemicarbazide hydroiodide, the identical product is again obtained.
  • Therapeutic Function Antihypertensive
guanoxabenz Preparation Products And Raw materials
Raw materials
Preparation Products
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guanoxabenz Spectrum
24047-25-4, guanoxabenzRelated Search:
  • 抑制剂
  • 化合物 GUANOXABENZ
  • 化合物 T11512
  • 胍诺沙苄
  • 24047-25-4
  • Hydrazinecarboximidamide, 2-[(2,6-dichlorophenyl)methylene]-N-hydroxy-
  • Hydroxyguanabenz
  • 43-663
  • 1-[(2,6-Dichlorobenzylidene)amino]-3-hydroxyguanidine
  • guanoxabenz

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