safracin B

Description

Safracin B (87578-99-2) is a novel antibiotic of the saframycin family produced byPseudomonas fluorescens.1Safracin B displays antitumor activity against L1210 and P388 leukemias and B16 melanoma. Compared with safracin A, the toxic and effective doses were much lower. Safracin B also prolonged the life of tumor-bearing mice to a greater extent than safracin A.2

Uses

Safracin B is a new antibiotics from the family of Safracin produced by Pseudomonas fluorescens A2-2. Safracin B is an antibiotic that exhibits anti-tumor properties.

in vivo

References

[1] Y IKEDA. Safracins, new antitumor antibiotics. I. Producing organism, fermentation and isolation.[J]. Journal of Antibiotics, 1983, 36 10: 1279-1283. DOI:10.7164/antibiotics.36.1279
[2] T OKUMOTO. Activity of safracins A and B, heterocyclic quinone antibiotics, on experimental tumors in mice.[J]. Journal of Antibiotics, 1985, 38 6: 767-771. DOI:10.7164/antibiotics.38.767