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bullatacin

bullatacin Structure
bullatacin
  • CAS No.102989-24-2
  • Chemical Name:bullatacin
  • CBNumber:CB41349878
  • Molecular Formula:C37H66O7
  • Formula Weight:622.92
  • MOL File:102989-24-2.mol
bullatacin Property
  • Melting point 45-48 °C(Solv: methanol (67-56-1); water (7732-18-5))
  • Boiling point 745.5±40.0 °C(Predicted)
  • Density 1.054±0.06 g/cm3(Predicted)
  • pka 14.46±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

bullatacin Chemical Properties,Usage,Production

  • Uses Asimicin (Bullatacin) is antitumor acetogenin that can be isolated from the bark and seeds of the pawpaw tree, Asimina trilobal Dunal. Asimicin inhibits mitochondrial respiration through the inhibition of complex I. Asimicin shows toxicity to Aphis gossypii, mosquito larvae and mammalian[1][2][3][4].
  • Anticancer Research Bullatacin is a bis(tetrahydrofuranoid) fatty acid lactone found in some fruits fromAnnonaceae family. It is a member of acetogenin class of phytochemicals. It fightsagainst the MDR phenotype of human mammary adenocarcinoma. It has showsantitumor properties by induction of chromatin migration and tumor cellcondensation followed by apoptosis (Oberlies et al. 1997; Desai et al. 2008).
  • References [1] Kawamata T, et al. Convergent Total Synthesis of Asimicin via Decarbonylative Radical Dimerization. Chemistry. 2018 Dec 17;24(71):18907-18912. DOI:10.1002/chem.201805317
    [2] Zhao GX, et al. Asimin, asiminacin, and asiminecin: novel highly cytotoxic asimicin isomers from Asimina triloba. J Med Chem. 1994 Jun 24;37(13):1971-6. DOI:10.1021/jm00039a009
    [3] Ligang Zhou, et al. Secondary Metabolites with Antinematodal Activity from Higher Plants. Studies in Natural Products Chemistry. Volume 37, 2012, Pages 67-114.
    [4] E. David Morgan and Ian D. Wilson. Insect Hormones and Insect Chemical Ecology. Comprehensive Natural Products Chemistry. Volume 8, 1999, Pages 263-375.
bullatacin Preparation Products And Raw materials
Raw materials
Preparation Products
bullatacin Suppliers
Global(4)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
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  • Supplier： TargetMol Chemicals Inc.
  • Tel： 15002134094
  • Email：marketing@targetmol.cn
  • Country：China
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bullatacin Spectrum
102989-24-2, bullatacinRelated Search:
  • 抑制剂
  • 化合物 ASIMICIN
  • 化合物 T25115
  • 泡番荔枝辛
  • 102989-24-2
  • 2(5H)-Furanone, 3-[(2R,13R)-2,13-dihydroxy-13-[(2R,2'R,5R,5'R)-octahydro-5'-[(1R)-1-hydroxyundecyl][2,2'-bifuran]-5-yl]tridecyl]-5-methyl-, (5S)-
  • bullatacin

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