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leucettamine A
leucettamine A
- CAS No.151124-32-2
- Chemical Name:leucettamine A
- CBNumber:CB41345986
- Molecular Formula:C30H52N2O2
- Formula Weight:472.75
- MOL File:151124-32-2.mol
leucettamine A Property
- Boiling point 606.8±55.0 °C(Predicted)
- Density 0.966±0.06 g/cm3(Predicted)
- pka 12.56±0.45(Predicted)
- Symbol(GHS)
- Signal word
- Hazard statements
- Precautionary statements
leucettamine A Chemical Properties,Usage,Production
- Uses Leucettamol A is an inhibitor of Ubc13 (ubiquitin E2 enzyme)-Uev1A interaction, with an IC50 of 50 μg/mL. Leucettamol A can potentially activate the expression of cancer suppressor p53 and is a precursor of anticancer agents. Leucettamol A can be isolated from a marine sponge, Leucetta aff. Microrhaphis[1][2].
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References
[1] Sachiko Tsukamoto, et al. Leucettamol A: a new inhibitor of Ubc13-Uev1A interaction isolated from a marine sponge, Leucetta aff. Microrhaphis. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6319-20. DOI:10.1016/j.bmcl.2008.10.110
[2] Kimberli M Helms, et al. Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K. Nat Prod Commun. 2011 Oct;6(10):1411-6. PMID:22164771
leucettamine A Preparation Products And Raw materials
Raw materials
Preparation Products
Global(1)Suppliers
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Supplier:
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- Country:United States
- ProdList:32159
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151124-32-2, leucettamine ARelated Search:
- 化合物 T27815
- 151124-32-2
- 5,8,11,14,17,20-Triacontahexaene-3,28-diol, 2,29-diamino-, (2R,3S,5Z,8Z,11Z,14Z,17Z,20Z,28S,29R)-
- leucettamine A