ChemicalBook > CAS DataBase List > geninthiocin
geninthiocin
- CAS No.158792-27-9
- Chemical Name:geninthiocin
- CBNumber:CB41333237
- Molecular Formula:C50H49N15O15S
- Formula Weight:1132.08
- MOL File:158792-27-9.mol
geninthiocin Property
- Density 1.54±0.1 g/cm3(Predicted)
- storage temp. Store at -20°C
- solubility DMF: soluble; DMSO: soluble; Ethanol: slightly soluble
- form White to off-white amorphous powder.
- pka 10.01±0.60(Predicted)
- Symbol(GHS)
- Signal word
- Hazard statements
- Precautionary statements
geninthiocin Chemical Properties,Usage,Production
- Description Geninthiocin A is a cyclic thiopeptide bacterial metabolite originally isolated from Streptomyces sp. DD84. It is active against a variety of Gram-positive bacteria (MICs = 0.2-4 μg/ml), the Gram-negative bacterium C. violaceum (MIC = 19 μg/ml), and the fungus M. hiemalis (MIC = 38 μg/ml). Geninthiocin A also induces tipA promoter transcription with a minimum induction concentration of 1.2 ng/ml.
- Uses Geninthiocin is a thiopeptide antibiotic tipA gene activator.
- Uses Geninthiocin, a thiopeptide antibiotic isolated from a Streptomyces sp., is a potent activator of the tipA gene, a bacterial transcription regulator involved in multidrug resistance. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines, whereas the related dedialanyl geninthiocin shows the reverse selectivity. Geninthiocin is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.
geninthiocin Preparation Products And Raw materials
Raw materials
Preparation Products
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158792-27-9, geninthiocinRelated Search:
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- 抑制剂
- 微生物代谢物
- C50H49N15O15S
- 生殖素
- 京尼噻菌素
- 158792-27-9
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- Geninthiocin A
- PubChem ID: 16129809
- 14-DeMethylberinaMycin
- geninthiocin
